Immunoisolation of pancreatic islets via thin-layer surface modification
Islet transplantation is an alternative method of replacing exogenous insulin to treat type 1
diabetes. However, transplantation of allo-or xenograft islets causes the activation of host's …
diabetes. However, transplantation of allo-or xenograft islets causes the activation of host's …
Recent progress in porcine islet isolation, culture and engraftment strategies for xenotransplantation
A plethora of different culture media and supplements have been tested; however, a unique
best culture system for NPIs is still missing. New insights, for example from single-cell …
best culture system for NPIs is still missing. New insights, for example from single-cell …
Expression of pluripotency‐related genes is highly dependent on trichostatin A‐assisted epigenomic modulation of porcine mesenchymal stem cells analysed for …
M Samiec, J Romanek, D Lipiński… - Animal Science …, 2019 - Wiley Online Library
The present study sought to examine whether trichostatin A (TSA)‐assisted epigenetic
transformation of porcine bone marrow (BM)‐derived mesenchymal stem cells (BM‐MSCs) …
transformation of porcine bone marrow (BM)‐derived mesenchymal stem cells (BM‐MSCs) …
Mesenchymal stem cells alleviate hypoxia-induced oxidative stress and enhance the pro-survival pathways in porcine islets
Y Tan, W Nie, C Chen, X He, Y Xu… - Experimental …, 2019 - journals.sagepub.com
Islet transplantation is a promising treatment for selected patients with type 1 diabetes
mellitus (T1DM). Hypoxia and oxidative stress are major causes of damage to transplanted …
mellitus (T1DM). Hypoxia and oxidative stress are major causes of damage to transplanted …
Three-dimensional vascularized β-cell spheroid tissue derived from human induced pluripotent stem cells for subcutaneous islet transplantation in a mouse model of …
S Takaichi, Y Tomimaru, T Akagi, S Kobayashi… - …, 2022 - journals.lww.com
Background. Islet transplantation is an effective replacement therapy for type 1 diabetes
(T1D) patients. However, shortage of donor organ for allograft is obstacle for further …
(T1D) patients. However, shortage of donor organ for allograft is obstacle for further …
Hydrogel materials for the application of islet transplantation
L Xu, Y Guo, Y Huang, Y Xu, Y Lu… - Journal of biomaterials …, 2019 - journals.sagepub.com
Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes
cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any …
cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any …
High mobility group box 1 secretion blockade results in the reduction of early pancreatic islet graft loss
H Chung, SJ Hong, SW Choi, JY Koo, M Kim… - Biochemical and …, 2019 - Elsevier
Pancreatic islet transplantation has been known as the best cure for patients suffering from
severe type 1 diabetes mellitus (T1DM). Despite meaningful advances in human allogeneic …
severe type 1 diabetes mellitus (T1DM). Despite meaningful advances in human allogeneic …
Bone marrow-derived mesenchymal stem cells improve rat islet graft revascularization by upregulating ISL1
Y Wang, JW Wang, Y Li, XH Tian, XS Feng… - Stem Cells, 2021 - academic.oup.com
Revascularization of the islet transplant is a crucial step that defines the success rate of
patient recovery. Bone marrow-derived mesenchymal stem cells (BMSCs) have been …
patient recovery. Bone marrow-derived mesenchymal stem cells (BMSCs) have been …
From insulin injections to islet transplantation: An overview of the journey
MB Paget, HE Murray, CJ Bailey… - Diabetes, Obesity and …, 2022 - Wiley Online Library
Abstract When, in 1869, Paul Langerhans detected the “islands of tissue” in the pancreas,
he took the first step on a journey towards islet transplantation as a treatment for type 1 …
he took the first step on a journey towards islet transplantation as a treatment for type 1 …
Diabetes current and future translatable therapies
FA Gonzalez-Sanchez, TM Sanchez-Huerta… - Endocrine, 2024 - Springer
Diabetes is one of the major diseases and concerns of public health systems that affects
over 200 million patients worldwide. It is estimated that 90% of these patients suffer from …
over 200 million patients worldwide. It is estimated that 90% of these patients suffer from …