Islet transplantation is an alternative method of replacing exogenous insulin to treat type 1
diabetes. However, transplantation of allo-or xenograft islets causes the activation of host's …

A plethora of different culture media and supplements have been tested; however, a unique
best culture system for NPIs is still missing. New insights, for example from single-cell …

The present study sought to examine whether trichostatin A (TSA)‐assisted epigenetic
transformation of porcine bone marrow (BM)‐derived mesenchymal stem cells (BM‐MSCs) …

Islet transplantation is a promising treatment for selected patients with type 1 diabetes
mellitus (T1DM). Hypoxia and oxidative stress are major causes of damage to transplanted …

Background. Islet transplantation is an effective replacement therapy for type 1 diabetes
(T1D) patients. However, shortage of donor organ for allograft is obstacle for further …

Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes
cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any …

Pancreatic islet transplantation has been known as the best cure for patients suffering from
severe type 1 diabetes mellitus (T1DM). Despite meaningful advances in human allogeneic …

Revascularization of the islet transplant is a crucial step that defines the success rate of
patient recovery. Bone marrow-derived mesenchymal stem cells (BMSCs) have been …

Abstract When, in 1869, Paul Langerhans detected the “islands of tissue” in the pancreas,
he took the first step on a journey towards islet transplantation as a treatment for type 1 …

Diabetes is one of the major diseases and concerns of public health systems that affects
over 200 million patients worldwide. It is estimated that 90% of these patients suffer from …