As the third most severe cancer in the world, colorectal cancer (CRC) is of high concern to
global health concerns. Aging, unhealthy lifestyles, and genetic factors contribute to CRC …

Prostate cancer (PCa) has a distinct molecular signature, including characteristic
chromosomal translocations, gene deletions and defective DNA damage repair …

Molecular algorithms may estimate the risk of recurrence and death for patients with
endometrial cancer (EC) and may impact treatment decisions. To detect microsatellite …

Colorectal cancer (CRC) ranks third in terms of cancer incidence worldwide and is
responsible for 8% of all deaths globally. Approximately 10% of CRC cases are caused by …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with
high mortality. Most patients present with an advanced stage of the disease, highlighting the …

Lynch Syndrome (LS) is a hereditary cancer syndrome caused by pathogenic germline
variants in one of the four mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. It …

Simple Summary Lynch syndrome (LS) is an inherited genetic condition caused by germline
mutations in DNA mismatch repair (MMR) genes. It is associated with a predisposition to …

The present manuscript aimed to review the historical development and most important
contributions regarding Lynch Syndrome since its first description, more than a century ago …

Colorectal cancer (CRC) is one of the most widespread tumor types, and it stands as the
second leading cause of disease-related mortality globally. Due to its adverse effects, which …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second
leading cause of cancer death worldwide. The leading risk factors for CRC include male …