It is now well accepted that many tumors undergo a process of clonal selection which means
that tumor antigens arising at various stages of tumor progression are likely to be …

Fetal bovine serum (FBS) remains widely used as a supplement in cell culture media used
in the isolation and expansion of mesenchymal stromal cells (MSC) despite longstanding …

Degenerative joint disease is one of the main causes of equine early retirement from
pleasure riding or a performance career. The disease is initially triggered by an abnormal …

Abstract Background Mesenchymal stem cells (MSCs) secrete paracrine factors and
extracellular matrix proteins that contribute to their ability to support tissue healing and …

Natural killer (NK) cells represent a subset of CD3-CD7+ CD56+/dim lymphocytes with
cytotoxic and suppressor activity against virus-infected cells and cancer cells. The overall …

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology with a high rate of
disability. Traditional treatments for RA remain a challenging issue. For example …

Poor healing of tendon and ligament lesions often results in early retirement of sport horses.
Therefore, regenerative therapies are being explored as potentially promising treatment for …

The therapeutic potential of the mesenchymal stromal cell (MSC) secretome, consisting of all
molecules secreted by MSCs, is intensively studied. MSCs can be readily isolated …

Mesenchymal stem cell (MSC) transplantation therapy appears to be an ideal strategy for
repairing structural defects and restoring the functions of diseased tissues and organs …

The immunomodulatory properties of equine mesenchymal stem cells (MSCs) are important
for their therapeutic potential and for their facilitating role in their escape from immune …