Cell cycle regulation of stem cells by microRNAs

MMJ Mens, M Ghanbari - Stem cell reviews and reports, 2018 - Springer
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the
regulation of gene expression. They are involved in the fine-tuning of fundamental biological …

MicroRNAs as new biomarkers for diagnosis and prognosis, and as potential therapeutic targets in acute myeloid leukemia

S Trino, D Lamorte, A Caivano, I Laurenzana… - International journal of …, 2018 - mdpi.com
Acute myeloid leukemias (AML) are clonal disorders of hematopoietic progenitor cells which
are characterized by relevant heterogeneity in terms of phenotypic, genotypic, and clinical …

miR-29b-3p suppresses the malignant biological behaviors of AML cells via inhibiting NF-κB and JAK/STAT signaling pathways by targeting HuR

YJ Tang, W Wu, QQ Chen, SH Liu, ZY Zheng, ZL Cui… - BMC cancer, 2022 - Springer
Background HuR/ELAVL1 (embryonic lethal abnormal vision 1) was a downstream target of
miR-29b in some cancer cells. HuR protein exerts important prognostic effects of involving in …

MicroRNA-21 over expression in umbilical cord blood hematopoietic stem progenitor cells by leukemia microvesicles

F Razmkhah, M Soleimani, S Ghasemi… - Genetics and Molecular …, 2019 - SciELO Brasil
Microvesicles are able to induce the cell of origin's phenotype in a target cell. MicroRNA-21,
as an oncomir, is up-regulated in almost all cancer types such as leukemia which results in …

[HTML][HTML] Characteristics of leukemic stem cells in acute leukemia and potential targeted therapies for their specific eradication

Q Hansen, C Bachas, L Smit, J Cloos - Cancer Drug Resistance, 2022 - ncbi.nlm.nih.gov
In acute myeloid leukemia (AML), a small cell population that contains stem cell features
such as lack of differentiation, self-renewal potential, and drug resistance, can be identified …

Genome-wide identification of microRNA signatures associated with stem/progenitor cells in Philadelphia chromosome-positive acute lymphoblastic leukemia

E Valiollahi, JM Ribera, E Genescà… - Molecular biology reports, 2019 - Springer
Acute lymphoblastic leukemia (ALL) is a malignant transformation with uncontrolled
proliferation of lymphoid precursor cells within bone marrow including a dismal prognosis …

Multi-omics analysis of DNMT3A-and NPM1-mutated acute myeloid leukemia

C Andresen - 2023 - archiv.ub.uni-heidelberg.de
Acute myeloid leukemia (AML) represents a genetically heterogeneous group of aggressive
myeloid malignancies arising from clonal expansion of aberrant, myeloid-primed …

HuR targeted by miR-29b-3p suppresses the malignant biological behaviors of AML cells via the NF-κB and JAK/STAT signaling pathways

YJ Tang, W Wu, QQ Chen, SH Liu, ZY Zheng, ZL Cui… - 2021 - researchsquare.com
Background: HuR/ELAVL1 (embryonic lethal abnormal vision 1) protein exerts important
prognostic effects of involving in the pathogenesis and development of acute myeloid …

KML VE KML LÖSEMİK KÖK HÜCRESİ ARASINDA MİKRORNA EKSPRESYON DEĞİŞİMLERİNİN DEĞERLENDİRİLMESİ

M Pehlivan, M Soyöz, HİK Çöven, B Çerçi… - Medical Journal of …, 2020 - dergipark.org.tr
Amaç: Kronik Miyeloid Lösemi (KML), hematopoetik kök hücreden (HKH) köken alan
miyeloproliferatif bir hastalıktır. MikroRNA'lar, transkripsiyon sonrası gen ekspresyonunu …

Methods and pharmaceutical compositions for the treatment of acute myeloid leukemia by eradicating leukemic stem cells

J Sarry, C Larrue, C Recher - 2020 - Google Patents
C12N15/113—Non-coding nucleic acids modulating the expression of genes, eg antisense
oligonucleotides; Antisense DNA or RNA; Triplex-forming oligonucleotides; Catalytic nucleic …