Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
CEACAM1 structure and function in immunity and its therapeutic implications
The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion
molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for …
molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for …
[HTML][HTML] Proton detected solid-state NMR of membrane proteins at 28 Tesla (1.2 GHz) and 100 kHz magic-angle spinning
E Nimerovsky, KT Movellan, XC Zhang, MC Forster… - Biomolecules, 2021 - mdpi.com
The available magnetic field strength for high resolution NMR in persistent superconducting
magnets has recently improved from 23.5 to 28 Tesla, increasing the proton resonance …
magnets has recently improved from 23.5 to 28 Tesla, increasing the proton resonance …
NMR as a tool to investigate the structure, dynamics and function of membrane proteins
B Liang, LK Tamm - Nature structural & molecular biology, 2016 - nature.com
Membrane-protein NMR occupies a unique niche for determining structures, assessing
dynamics, examining folding, and studying the binding of lipids, ligands and drugs to …
dynamics, examining folding, and studying the binding of lipids, ligands and drugs to …
[HTML][HTML] Temperature effects on cellular host-microbe interactions explain continent-wide endosymbiont prevalence
Endosymbioses influence host physiology, reproduction, and fitness, but these relationships
require efficient microbe transmission between host generations to persist. Maternally …
require efficient microbe transmission between host generations to persist. Maternally …
Distinct Wolbachia localization patterns in oocytes of diverse host species reveal multiple strategies of maternal transmission
YA Radousky, MTJ Hague, S Fowler, E Paneru… - Genetics, 2023 - academic.oup.com
A broad array of endosymbionts radiate through host populations via vertical transmission,
yet much remains unknown concerning the cellular basis, diversity, and routes underlying …
yet much remains unknown concerning the cellular basis, diversity, and routes underlying …
[HTML][HTML] Molecular docking simulation studies identifies potential natural product derived-antiwolbachial compounds as filaricides against onchocerciasis
Onchocerciasis is the leading cause of blindness and severe skin lesions which remain a
major public health problem, especially in tropical areas. The widespread use of antibiotics …
major public health problem, especially in tropical areas. The widespread use of antibiotics …
Lipid internal dynamics probed in nanodiscs
Nanodiscs offer a very promising tool to incorporate membrane proteins into native‐like lipid
bilayers and an alternative to liposomes to maintain protein functions and protein–lipid …
bilayers and an alternative to liposomes to maintain protein functions and protein–lipid …
[HTML][HTML] Solution NMR spectroscopy of membrane proteins
GI Danmaliki, PM Hwang - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
Integral membrane proteins (IMPs) perform unique and indispensable functions in the cell,
making them attractive targets for fundamental research and drug discovery. Developments …
making them attractive targets for fundamental research and drug discovery. Developments …
The power, pitfalls and potential of the nanodisc system for NMR-based studies
The choice of a suitable membrane mimicking environment is of fundamental importance for
the characterization of structure and function of membrane proteins. In this respect, usage of …
the characterization of structure and function of membrane proteins. In this respect, usage of …