International Union of Basic and Clinical Pharmacology. CVI: GABAA receptor subtype-and function-selective ligands: key issues in translation to humans
W Sieghart, MM Savić - Pharmacological reviews, 2018 - ASPET
GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
Dopamine: an immune transmitter
The dopaminergic system controls several vital central nervous system functions, including
the control of movement, reward behaviors and cognition. Alterations of dopaminergic …
the control of movement, reward behaviors and cognition. Alterations of dopaminergic …
Gut microbiota alterations promote traumatic stress susceptibility associated with p-cresol-induced dopaminergic dysfunctions
S Laudani, SA Torrisi, S Alboni… - Brain, Behavior, and …, 2023 - Elsevier
Mounting evidence suggests a link between gut microbiota abnormalities and post-traumatic
stress disorder (PTSD). However, whether and how the gut microbiota influences PTSD …
stress disorder (PTSD). However, whether and how the gut microbiota influences PTSD …
[HTML][HTML] A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice
Translational animal models for studying post-traumatic stress disorder (PTSD) are valuable
for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These …
for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These …
Neuronal dopamine D3 receptors: translational implications for preclinical research and CNS disorders
B Kiss, I Laszlovszky, B Krámos, A Visegrády, A Bobok… - Biomolecules, 2021 - mdpi.com
Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …
and periphery, exerts its actions through five types of receptors which belong to two major …
Current drug treatments targeting dopamine D3 receptor
Dopamine receptors (DR) have been extensively studied, but only in recent years they
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …
α6-Containing GABAA receptors: functional roles and therapeutic potentials
GABAA receptors containing the α 6 subunit are highly expressed in cerebellar granule cells
and less abundantly in many other neuronal and peripheral tissues. Here, we for the first …
and less abundantly in many other neuronal and peripheral tissues. Here, we for the first …
The epistatic interaction between the dopamine D3 receptor and dysbindin-1 modulates higher-order cognitive functions in mice and humans
GM Leggio, SA Torrisi, R Mastrogiacomo, D Mauro… - Molecular …, 2021 - nature.com
The dopamine D2 and D3 receptors are implicated in schizophrenia and its
pharmacological treatments. These receptors undergo intracellular trafficking processes that …
pharmacological treatments. These receptors undergo intracellular trafficking processes that …
PACAP and VIP mitigate rotenone-induced inflammation in BV-2 microglial cells
Rotenone is a commercial pesticide commonly used to model Parkinson's disease (PD) due
to its ability to induce dopaminergic degeneration. Studies have confirmed that rotenone …
to its ability to induce dopaminergic degeneration. Studies have confirmed that rotenone …
α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia
HR Tzeng, MT Lee, PC Fan, DE Knutson, TH Lai… - …, 2021 - Springer
Migraine is caused by hyperactivity of the trigeminovascular system, where trigeminal
ganglia (TG) play an important role. This hyperactivity might originate from an …
ganglia (TG) play an important role. This hyperactivity might originate from an …