International Union of Basic and Clinical Pharmacology. CVI: GABAA receptor subtype-and function-selective ligands: key issues in translation to humans

W Sieghart, MM Savić - Pharmacological reviews, 2018 - ASPET
GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …

Dopamine: an immune transmitter

ST Broome, K Louangaphay, KA Keay… - Neural regeneration …, 2020 - journals.lww.com
The dopaminergic system controls several vital central nervous system functions, including
the control of movement, reward behaviors and cognition. Alterations of dopaminergic …

Gut microbiota alterations promote traumatic stress susceptibility associated with p-cresol-induced dopaminergic dysfunctions

S Laudani, SA Torrisi, S Alboni… - Brain, Behavior, and …, 2023 - Elsevier
Mounting evidence suggests a link between gut microbiota abnormalities and post-traumatic
stress disorder (PTSD). However, whether and how the gut microbiota influences PTSD …

[HTML][HTML] A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice

SA Torrisi, G Lavanco, OM Maurel, W Gulisano… - Neurobiology of …, 2021 - Elsevier
Translational animal models for studying post-traumatic stress disorder (PTSD) are valuable
for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These …

Neuronal dopamine D3 receptors: translational implications for preclinical research and CNS disorders

B Kiss, I Laszlovszky, B Krámos, A Visegrády, A Bobok… - Biomolecules, 2021 - mdpi.com
Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …

Current drug treatments targeting dopamine D3 receptor

GM Leggio, C Bucolo, CBM Platania… - Pharmacology & …, 2016 - Elsevier
Dopamine receptors (DR) have been extensively studied, but only in recent years they
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …

α6-Containing GABAA receptors: functional roles and therapeutic potentials

W Sieghart, LC Chiou, M Ernst, J Fabjan… - Pharmacological …, 2022 - ASPET
GABAA receptors containing the α 6 subunit are highly expressed in cerebellar granule cells
and less abundantly in many other neuronal and peripheral tissues. Here, we for the first …

The epistatic interaction between the dopamine D3 receptor and dysbindin-1 modulates higher-order cognitive functions in mice and humans

GM Leggio, SA Torrisi, R Mastrogiacomo, D Mauro… - Molecular …, 2021 - nature.com
The dopamine D2 and D3 receptors are implicated in schizophrenia and its
pharmacological treatments. These receptors undergo intracellular trafficking processes that …

PACAP and VIP mitigate rotenone-induced inflammation in BV-2 microglial cells

ST Broome, G Musumeci, A Castorina - Journal of Molecular Neuroscience, 2022 - Springer
Rotenone is a commercial pesticide commonly used to model Parkinson's disease (PD) due
to its ability to induce dopaminergic degeneration. Studies have confirmed that rotenone …

α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia

HR Tzeng, MT Lee, PC Fan, DE Knutson, TH Lai… - …, 2021 - Springer
Migraine is caused by hyperactivity of the trigeminovascular system, where trigeminal
ganglia (TG) play an important role. This hyperactivity might originate from an …