Reactive oxygen species (ROS) initially considered as only damaging agents in living
organisms further were found to play positive roles also. This paper describes ROS …

Prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), and thromboxane A2 (TXA2)
together form the prostanoid family of lipid mediators. As autacoids, these five primary …

Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis
(RRMS). The redox master regulator Nrf2, essential for redox balance, is a target of DMF, but …

Oxidized low-density lipoprotein (oxLDL) is a well-recognized proatherogenic particle that
functions in atherosclerosis. In this study, we established conditions to generate human …

Lipid autacoids derived from n-3/n-6 polyunsaturated fatty acids (PUFA) are some of the
earliest signals triggered by an inflammatory reaction. They are acting also as essential …

Misregulation of oxidative and antioxidative processes in the organism–oxidative stress–
contributes to the pathogenesis of different diseases, eg inflammatory or neurodegenerative …

F2-Isoprostanes (IsoPs) are isomers of prostaglandin F2α formed from the nonenzymatic
free radical-catalyzed peroxidation of arachidonic acid. Since discovery of these molecules …

Mass spectrometry (MS) has become an indispensable technique in the analysis of fatty
acids (FAs) and fatty acyls due to its superior sensitivity and selectivity. Chemical …

Oxidative stress and inflammation play important roles in disease development. This study
intended to evaluate the anti-inflammatory and antioxidant potential of Echium plantagineum …

For a long time, sample preparation was unrecognized as a critical issue in the analytical
methodology, thus limiting the performance that could be achieved. However, the …