Physical models of collective cell migration

R Alert, X Trepat - Annual Review of Condensed Matter Physics, 2020 - annualreviews.org
Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

Continuum models of collective cell migration

S Banerjee, MC Marchetti - Cell migrations: Causes and functions, 2019 - Springer
Collective cell migration plays a central role in tissue development, morphogenesis, wound
repair and cancer progression. With the growing realization that physical forces mediate cell …

Active wetting of epithelial tissues

C Pérez-González, R Alert, C Blanch-Mercader… - Nature physics, 2019 - nature.com
Abstract Development, regeneration and cancer involve drastic transitions in tissue
morphology. In analogy with the behaviour of inert fluids, some of these transitions have …

Collective cell migration without proliferation: density determines cell velocity and wave velocity

S Tlili, E Gauquelin, B Li, O Cardoso… - Royal Society …, 2018 - royalsocietypublishing.org
Collective cell migration contributes to embryogenesis, wound healing and tumour
metastasis. Cell monolayer migration experiments help in understanding what determines …

Active fingering instability in tissue spreading

R Alert, C Blanch-Mercader, J Casademunt - Physical review letters, 2019 - APS
During the spreading of epithelial tissues, the advancing tissue front often develops
fingerlike protrusions. Their resemblance to traditional viscous fingering patterns in driven …

Role of the cell cycle in collective cell dynamics

J Li, SK Schnyder, MS Turner, R Yamamoto - Physical Review X, 2021 - APS
Cells coexist together in colonies or as tissues. Their behavior is controlled by an interplay
between intercellular forces and biochemical regulation. We develop a simple model of the …

Control of cell colony growth by contact inhibition

SK Schnyder, JJ Molina, R Yamamoto - Scientific reports, 2020 - nature.com
Contact inhibition is a cell property that limits the migration and proliferation of cells in
crowded environments. Here we investigate the growth dynamics of a cell colony composed …

From cells to tissue: A continuum model of epithelial mechanics

S Ishihara, P Marcq, K Sugimura - Physical Review E, 2017 - APS
A two-dimensional continuum model of epithelial tissue mechanics was formulated using
cellular-level mechanical ingredients and cell morphogenetic processes, including cellular …

Role of substrate stiffness in tissue spreading: Wetting transition and tissue durotaxis

R Alert, J Casademunt - Langmuir, 2018 - ACS Publications
Living tissues undergo wetting transitions: On a surface, they can either form a dropletlike
cell aggregate or spread as a monolayer of migrating cells. Tissue wetting depends not only …

Competition between cell types under cell cycle regulation with apoptosis

J Li, SK Schnyder, MS Turner, R Yamamoto - Physical Review Research, 2022 - APS
Competition between different cell types plays a crucial role in bacterial ecology,
developmental biology, and tumor growth. We study how cells compete in 2D by using both …