Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Recent findings suggest that the cellular and extracellular materials surrounding the
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

Abnormal glucose metabolism is central to neurodegeneration, and considerable evidence
suggests that abnormalities in key enzymes of the tricarboxylic acid (TCA) cycle underlie the …

Genetic-driven deregulation of the Wnt pathway is crucial but not sufficient for colorectal
cancer (CRC) tumorigenesis. Here, we show that environmental glutamine restriction further …

A key challenge in the clinical management and cause of treatment failure of prostate cancer
(PCa) is its molecular, cellular and clinical heterogeneity. Modelling systems that fully …

Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the nutrient poor
microenvironment remain unexplored. In melanoma, tumour cells often experience low …

The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is
responsible for the epigenetic regulation of gene expression through specific methylation of …

Background Resistance to platinum-based chemotherapy is a major cause of therapeutic
failure during the treatment of epithelial ovarian cancer (EOC) patients. Our study aims to …

Nicotinamide N-methyltransferase (NNMT) has been reported to be linked to methylation
reprogramming in cancer cells. However, the role of NNMT in the tumour microenvironment …