Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective
edge tools for the investigation of cell biology and disease diagnosis because of their …

Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic
endo/lysosomal compartments where they play a vital role in intracellular protein …

Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific
monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the …

Background Cysteine cathepsins are normally found in the lysosomes where they are
involved in intracellular protein turnover. Their ability to degrade the components of the …

Proteases are important for multiple processes during malignant progression, including
tumor angiogenesis, invasion and metastasis. Recent evidence reveals that tumor …

Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms
ranging from gene amplification to post-transcriptional modification. Their localization within …

The tumour microenvironment regulates tumour progression and the spread of cancer in the
body. Targeting the stromal cells that surround cancer cells could, therefore, improve the …

Early cancers are avascular and hence, profoundly acidic. Pre-malignant cells must adapt to
acidosis to thrive in this hostile microenvironment. Here, we investigate MCF-7 cells that are …

Proteolysis in close vicinity of tumor cells is a hallmark of cancer invasion and metastasis.
We show here that mouse mammary tumor virus–polyoma middle T antigen (PyMT) …

Polymersomes are stable vesicles prepared from amphiphilic polymers and are more stable
compared with liposomes. Although these nanovesicles have many attractive properties for …