Long non-coding RNA (lncRNA) was originally defined as the representative of the non-
coding RNAs and unable to encode. However, recent reports suggest that some lncRNAs …

Gene expression in human tissue has primarily been studied on the transcriptional level,
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …

Single-cell sequencing methods have enabled in-depth analysis of the diversity of cell types
and cell states in a wide range of organisms. These tools focus predominantly on …

Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …

Transfer RNAs are essential for translating genetic information into proteins. The human
genome contains hundreds of predicted tRNA genes, many in multiple copies. How their …

Ribosome profiling (Ribo-seq) is a powerful technology for globally monitoring RNA
translation; ranging from codon occupancy profiling, identification of actively translated open …

Translation modulates the timing and amplification of gene expression after transcription.
Brain development requires uniquely complex gene expression patterns, but large-scale …

Synonymous codon choice can have dramatic effects on ribosome speed and protein
expression. Ribosome profiling experiments have underscored that ribosomes do not move …

The codon stabilization coefficient (CSC) is derived from the correlation between each
codon frequency in transcripts and mRNA half-life experimental data. In this work, we used …

Protein synthesis from mRNA is an energy-intensive and tightly controlled cellular process.
Translation elongation is a well-coordinated, multifactorial step in translation that undergoes …