A paradox exists regarding the reinforcing properties of nicotine. The abuse liability
associated with smoking equals or exceeds that of other addictive drugs, yet the euphoric …

Cytochrome P450 (CYP) enzymes are responsible for the metabolism of many exogenous
and endogenous compounds. CYPs are abundant in the liver and are also expressed in …

Nicotine is a psychoactive ingredient in tobacco that significantly contributes to the harmful
tobacco smoking habit. Nicotine dependence is more prevalent than dependence on any …

The aversive aspects of withdrawal from chronic nicotine exposure are thought to be an
important motivational factor contributing to the maintenance of the tobacco habit in human …

Nicotine, primary component of tobaco produces craving and withdrawal effect both in
humans and animals. Nicotine shows a close resemblance to other addictive drugs in …

Declining cigarette use and spreading bans on smoking in public places in the United States
are encouraging the US cigarette industry to turn to another tobacco category, smokeless …

Lobeline, an alkaloidal constituent of Lobelia inflata LINN., has a long history of therapeutic
usage ranging from emetic and respiratory stimulant to tobacco smoking cessation agent …

Tobacco is a highly addictive drug and is one of the most widely abused drugs in the world.
The first part of this review explores the role of stressors and stress-associated psychiatric …

The harm produced by tobacco products is a result of frequent use of a highly toxic product.
Reducing the adverse public health impact of tobacco products might be most effectively …

Nornicotine, an endogenous tobacco alkaloid and minor nicotine metabolite, can catalyze
aldol reactions at physiological pH. Catalysis appears to be due to a covalent enamine …