Activation of p53 can occur in response to a number of cellular stresses, including DNA
damage, hypoxia and nucleotide deprivation. Several forms of DNA damage have been …

Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …

The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest
and apoptosis, in response to various types of stress1. The activity of p53 is abrogated by …

The tumour-suppressor p53 is a short-lived protein that is maintained at low, often
undetectable, levels in normal cells. Stabilization of the protein in response to an activating …

DNA-damaging agents signal to p53 through as yet unidentified posttranscriptional
mechanisms. Here we show that phosphorylation of human p53 at serine 15 occurs after …

The ATM protein, encoded by the gene responsible for the human genetic disorder ataxia
telangiectasia (AT), regulates several cellular responses to DNA breaks. ATM shares a …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

Phosphorylation at Ser-15 may be a critical event in the up-regulation and functional
activation of p53 during cellular stress. In this report we provide evidence that the ATM …

The p53 tumor suppressor protein is a sequence-specific transcription factor that modulates
the response of cells to DNA damage. Recent studies suggest that full transcriptional activity …

Exposure of mammalian cells to ionizing radiation (IR) induces a complex array of cellular
responses including cell cycle arrest and/or apoptosis. IR-induced G1 arrest has been …