Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches
IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …
Selectin-mediated signaling—Shedding light on the regulation of integrin activity in neutrophils
A Cappenberg, M Kardell, A Zarbock - Cells, 2022 - mdpi.com
As a consequence of tissue injury or infection, neutrophils are recruited in a stepwise
recruitment process from the bloodstream into the surrounding tissue. Selectins are a family …
recruitment process from the bloodstream into the surrounding tissue. Selectins are a family …
A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury
P Burkard, C Schonhart, T Vögtle, D Köhler, L Tang… - Blood, 2023 - ashpublications.org
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with
high morbidity and mortality. Excessive neutrophil infiltration into the pulmonary airspace is …
high morbidity and mortality. Excessive neutrophil infiltration into the pulmonary airspace is …
Neutrophil functional heterogeneity and implications for viral infections and treatments
Evidence suggests that neutrophils exert specialized effector functions during infection and
inflammation, and that these cells can affect the duration, severity, and outcome of the …
inflammation, and that these cells can affect the duration, severity, and outcome of the …
A jack of all trades–ADAM8 as a signaling hub in inflammation and cancer
L Cook, FG Gharzia, JW Bartsch, D Yildiz - The FEBS Journal, 2023 - Wiley Online Library
As a member of the family of A Disintegrin And Metalloproteinases (ADAM) ADAM8 is
preferentially expressed in lymphatic organs, immune cells, and tumor cells. The substrate …
preferentially expressed in lymphatic organs, immune cells, and tumor cells. The substrate …
siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury
IV Chernikov, YY Staroseletz, IS Tatarnikova… - International Journal of …, 2023 - mdpi.com
Acute lung injury is a complex cascade process that develops in response to various
damaging factors, which can lead to acute respiratory distress syndrome. Within this study …
damaging factors, which can lead to acute respiratory distress syndrome. Within this study …
Identification of novel core genes involved in Malignant transformation of inflamed colon tissue using a computational biology approach and verification in murine …
AV Markov, IA Savin, MA Zenkova… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a complex and multifactorial systemic disorder of the
gastrointestinal tract and is strongly associated with the development of colorectal cancer …
gastrointestinal tract and is strongly associated with the development of colorectal cancer …
The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome
Y Wang, C Zhu, P Li, Q Liu, H Li, C Yu, X Deng… - Frontiers in …, 2023 - frontiersin.org
Sepsis is defined as a life-threatening dysfunction due to a dysregulated host response to
infection. It is a common and complex syndrome and is the leading cause of death in …
infection. It is a common and complex syndrome and is the leading cause of death in …
Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism
M Cosenza-Contreras, A Schäfer, J Sing… - Neuro …, 2024 - academic.oup.com
Background There is an urgent need to better understand the mechanisms associated with
the development, progression, and onset of recurrence after initial surgery in glioblastoma …
the development, progression, and onset of recurrence after initial surgery in glioblastoma …
ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis
K Chen, H Tao, P Zhu, M Chu, X Li, Y Shi… - Arthritis Research & …, 2024 - Springer
Objective Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations
worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) …
worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) …