Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Selectin-mediated signaling—Shedding light on the regulation of integrin activity in neutrophils

A Cappenberg, M Kardell, A Zarbock - Cells, 2022 - mdpi.com
As a consequence of tissue injury or infection, neutrophils are recruited in a stepwise
recruitment process from the bloodstream into the surrounding tissue. Selectins are a family …

A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury

P Burkard, C Schonhart, T Vögtle, D Köhler, L Tang… - Blood, 2023 - ashpublications.org
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with
high morbidity and mortality. Excessive neutrophil infiltration into the pulmonary airspace is …

Neutrophil functional heterogeneity and implications for viral infections and treatments

L Chan, S Morovati, N Karimi, K Alizadeh… - Cells, 2022 - mdpi.com
Evidence suggests that neutrophils exert specialized effector functions during infection and
inflammation, and that these cells can affect the duration, severity, and outcome of the …

A jack of all trades–ADAM8 as a signaling hub in inflammation and cancer

L Cook, FG Gharzia, JW Bartsch, D Yildiz - The FEBS Journal, 2023 - Wiley Online Library
As a member of the family of A Disintegrin And Metalloproteinases (ADAM) ADAM8 is
preferentially expressed in lymphatic organs, immune cells, and tumor cells. The substrate …

siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury

IV Chernikov, YY Staroseletz, IS Tatarnikova… - International Journal of …, 2023 - mdpi.com
Acute lung injury is a complex cascade process that develops in response to various
damaging factors, which can lead to acute respiratory distress syndrome. Within this study …

Identification of novel core genes involved in Malignant transformation of inflamed colon tissue using a computational biology approach and verification in murine …

AV Markov, IA Savin, MA Zenkova… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a complex and multifactorial systemic disorder of the
gastrointestinal tract and is strongly associated with the development of colorectal cancer …

The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome

Y Wang, C Zhu, P Li, Q Liu, H Li, C Yu, X Deng… - Frontiers in …, 2023 - frontiersin.org
Sepsis is defined as a life-threatening dysfunction due to a dysregulated host response to
infection. It is a common and complex syndrome and is the leading cause of death in …

Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism

M Cosenza-Contreras, A Schäfer, J Sing… - Neuro …, 2024 - academic.oup.com
Background There is an urgent need to better understand the mechanisms associated with
the development, progression, and onset of recurrence after initial surgery in glioblastoma …

ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis

K Chen, H Tao, P Zhu, M Chu, X Li, Y Shi… - Arthritis Research & …, 2024 - Springer
Objective Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations
worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) …