Polymorphism of human cytochrome P450 enzymes and its clinical impact
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …
specific genes affect drug response. This article highlights current pharmacogenetic …
Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines
RJ Turesky, L Le Marchand - Chemical research in toxicology, 2011 - ACS Publications
Aromatic amines and heterocyclic aromatic amines (HAAs) are structurally related classes of
carcinogens that are formed during the combustion of tobacco or during the high …
carcinogens that are formed during the combustion of tobacco or during the high …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
[图书][B] Handbook of olfaction and gustation
RL Doty - 2015 - books.google.com
The largest collection of basic, clinical, and applied knowledge on the chemical senses ever
compiled in one volume, the third edition of Handbook of Olfaction and Gustation …
compiled in one volume, the third edition of Handbook of Olfaction and Gustation …
Contributions of human enzymes in carcinogen metabolism
S Rendic, FP Guengerich - Chemical research in toxicology, 2012 - ACS Publications
Considerable support exists for the roles of metabolism in modulating the carcinogenic
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …
Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity
SC Khojasteh, S Prabhu, JR Kenny… - European journal of …, 2011 - Springer
The majority of marketed small-molecule drugs undergo metabolism by hepatic Cytochrome
P450 (CYP) enzymes (Rendic 2002). Since these enzymes metabolize a structurally diverse …
P450 (CYP) enzymes (Rendic 2002). Since these enzymes metabolize a structurally diverse …
Human CYP2A6 is induced by estrogen via estrogen receptor
E Higashi, T Fukami, M Itoh, S Kyo, M Inoue… - Drug Metabolism and …, 2007 - ASPET
Human CYP2A6, which is predominantly expressed in liver, is a key enzyme responsible for
the metabolism of nicotine, coumarin, and some pharmaceutical drugs. CYP2A6 is also …
the metabolism of nicotine, coumarin, and some pharmaceutical drugs. CYP2A6 is also …
Understanding the gender disparity in bladder cancer risk: the impact of sex hormones and liver on bladder susceptibility to carcinogens
Y Zhang - Journal of Environmental Science and Health, Part C, 2013 - Taylor & Francis
It has long been known that bladder cancer (BC) incidence is approximately four-fold higher
in men than in women in the United States, and a similar disparity also exists in other …
in men than in women in the United States, and a similar disparity also exists in other …
Primary aromatic amines and cancer: Novel mechanistic insights using 4-aminobiphenyl as a model carcinogen
Aromatic amines are an important class of human carcinogens found ubiquitously in our
environment. It is estimated that 1 in 8 of all known or suspected human carcinogens is or …
environment. It is estimated that 1 in 8 of all known or suspected human carcinogens is or …
Structure, function, regulation and polymorphism of human cytochrome P450 2A6
YM Di, VDW Chow, LP Yang… - Current drug metabolism, 2009 - ingentaconnect.com
The CYP2A6 gene spans a region of approximately 6 kb pairs consisting of 9 exons and has
been mapped to the long arm of chromosome 19 (between 19q12 and 19q13. 2). The …
been mapped to the long arm of chromosome 19 (between 19q12 and 19q13. 2). The …