[HTML][HTML] The role of inflammation in age-related macular degeneration

W Tan, J Zou, S Yoshida, B Jiang… - International journal of …, 2020 - ncbi.nlm.nih.gov
Age-related macular degeneration (AMD) is a blinding eye disease which incidence
gradually increases with age. Inflammation participates in AMD pathogenesis, including …

[HTML][HTML] The complement system in age-related macular degeneration

A Armento, M Ueffing, SJ Clark - Cellular and Molecular Life Sciences, 2021 - Springer
Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD

U Gupta, S Ghosh, CT Wallace, P Shang, Y Xin… - Autophagy, 2023 - Taylor & Francis
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …

[HTML][HTML] Role of CD93 in Health and Disease

G Tossetta, F Piani, C Borghi, D Marzioni - Cells, 2023 - mdpi.com
CD93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp), is
a transmembrane glycoprotein encoded by a gene located on 20p11. 21 and composed of …

Age-related macular degeneration

M Fleckenstein, TDL Keenan, RH Guymer… - Nature reviews Disease …, 2021 - nature.com
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …

[HTML][HTML] Neovascular age-related macular degeneration: therapeutic management and new-upcoming approaches

F Ricci, F Bandello, P Navarra, G Staurenghi… - International journal of …, 2020 - mdpi.com
Age-related macular degeneration (AMD) constitutes a prevalent, chronic, and progressive
retinal degenerative disease of the macula that affects elderly people and cause central …

[HTML][HTML] Integration of eQTL and a single-cell atlas in the human eye identifies causal genes for age-related macular degeneration

LD Orozco, HH Chen, C Cox, KJ Katschke, R Arceo… - Cell reports, 2020 - cell.com
Age-related macular degeneration (AMD) is a leading cause of vision loss. To better
understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we …

[HTML][HTML] Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration

KS Lee, S Lin, DA Copland, AD Dick, J Liu - Journal of Neuroinflammation, 2021 - Springer
Age-related macular degeneration (AMD), a degenerative disease in the central macula
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …

Functional carbon quantum dots for ocular imaging and therapeutic applications

VB Kumar, I Sher, S Rencus‐Lazar, Y Rotenstreich… - Small, 2023 - Wiley Online Library
Carbon quantum dots (CDs) are a class of emerging carbonaceous nanomaterials that have
received considerable attention due to their excellent fluorescent properties, extremely small …

Age-related macular degeneration: A two-level model hypothesis

MP Rozing, JA Durhuus, MK Nielsen, Y Subhi… - Progress in retinal and …, 2020 - Elsevier
Age-related diseases, including age-related macular degeneration (AMD), are of growing
importance in a world where population ageing has become a dominant global trend …