Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a
growing concern due to limited therapeutic options. Gram-negative bacteria, specifically …

The emergence and spread of carbapenemase-producing carbapenem-resistant
Enterobacteriaceae (CP-CRE) are a significant clinical and public health concern. Reliable …

Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated
with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P …

Antimicrobial resistance to Pseudomonas aeruginosa is on the rise. In the absence of new
anti-pseudomonal drugs, clinicians have had to resort to older antimicrobials such as colistin …

Given the sparse antibiotic pipeline and the increasing prevalence of resistant organisms,
efforts should be made to optimise the pharmacodynamic exposure of currently available …

Bloodstream infections (BSIs) are frequent in ICU and is a prognostic factor of severe sepsis.
Community acquired BSIs usually due to susceptible bacteria should be clearly …

Background: Carbapenem-resistant Enterobacteriaceae (CRE) are an increasing cause of
nosocomial infection in hospitalized children worldwide. Few studies have investigated risk …

Beta-lactam antibiotics serve as a cornerstone in the management of bacterial infections
because of their wide spectrum of activity and low toxicity. Since resistance rates among …

The percentage of time that free drug concentrations remain above the MIC (f T> MIC) that is
necessary to prevent mortality among cefepime-treated patients with Gram-negative …

ABSTRACT The Clinical and Laboratory Standards Institute (CLSI) lowered the MIC
breakpoints for meropenem and imipenem from 4 mg/liter to 1 mg/liter for …