The P2X7 receptor in inflammatory diseases: angel or demon?
LEB Savio, P de Andrade Mello… - Frontiers in …, 2018 - frontiersin.org
Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …
extracellular milieu, being massively released by stressed or dying cells. Once outside the …
Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease
T Jiang, Q Sun, S Chen - Progress in neurobiology, 2016 - Elsevier
Oxidative stress reflects an imbalance between the overproduction and incorporation of free
radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free …
radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free …
Regulation of microglial functions by purinergic mechanisms in the healthy and diseased CNS
P Illes, P Rubini, H Ulrich, Y Zhao, Y Tang - Cells, 2020 - mdpi.com
Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …
The P2X7 receptor: central hub of brain diseases
R Andrejew, Á Oliveira-Giacomelli… - Frontiers in Molecular …, 2020 - frontiersin.org
The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …
The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression
G Burnstock, GE Knight - Purinergic signalling, 2018 - Springer
Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …
P2X7 receptor: an emerging target in central nervous system diseases
B Sperlágh, P Illes - Trends in pharmacological sciences, 2014 - cell.com
The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …
potential drug target because of its widespread involvement in inflammatory diseases as a …
P2X7 receptors amplify CNS damage in neurodegenerative diseases
P Illes - International Journal of Molecular Sciences, 2020 - mdpi.com
ATP is a (co) transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-
gated cationic channels termed P2X to induce rapid depolarization of the cell membrane …
gated cationic channels termed P2X to induce rapid depolarization of the cell membrane …
ATP as a multi-target danger signal in the brain
ATP is released in an activity-dependent manner from different cell types in the brain,
fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron …
fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron …
The microglial ATP‐gated ion channel P2X7 as a CNS drug target
A Bhattacharya, K Biber - Glia, 2016 - Wiley Online Library
Based on promising preclinical evidence, microglial P2X7 has increasingly being
recognized as a target for therapeutic intervention in neurological and psychiatric diseases …
recognized as a target for therapeutic intervention in neurological and psychiatric diseases …
Advances in the potential biomarkers of epilepsy
D Kobylarek, P Iwanowski, Z Lewandowska… - Frontiers in …, 2019 - frontiersin.org
Epilepsy is a group of chronic neurological disorders characterized by recurrent,
spontaneous, and unpredictable seizures. It is one of the most common neurological …
spontaneous, and unpredictable seizures. It is one of the most common neurological …