Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …

The use of hydrogels has garnered significant interest as biomaterial and drug delivery
platforms for anti-infective applications. For decades antimicrobial peptides have been …

Highlights•Heterogeneity in phenotype and growth rate of single cells affect stress
survival.•Single-cell stress responses in biofilms and interspecies interactions can alter …

Summary Background Carbapenemase-producing Enterobacterales (CPE), particularly
those producing metallo-β-lactamases, are among the most challenging antibiotic-resistant …

Transcription activation is established through extensive protein–protein and protein–DNA
interactions that allow an activator to engage and remodel RNA polymerase. SoxS, a global …

Antibiotic efflux is a mechanism that is well-documented in the phenotype of multidrug
resistance in bacteria. Efflux is considered as an early facilitating mechanism in the bacterial …

Governance of the endogenous gene regulatory network enables the navigation of cells
towards beneficial traits for recombinant protein production. CRISPRactivation and …

The distribution of fitness effects of mutation plays a central role in constraining protein
evolution. The underlying mechanisms by which mutations lead to fitness effects are …

Astaxanthin has been widely used as feed supplements in aquaculture, and the effects of
which on the growth, immunity, and antioxidant system of aquaculture animals have been …

The incidence of multidrug-resistant bacteria is increasing globally, with efflux pumps being
a fundamental platform limiting drug access and synergizing with other mechanisms of …