Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Amyloid-β (Aβ) and tau proteins currently represent the two most promising targets to treat
Alzheimer's disease. The most extensively developed method to treat the pathologic forms of …

The poly-l-proline type II (PPII) helix in recent years has emerged clearly as a structural class
not only of fibrillar proteins (in collagen, PPII is a dominant conformation) but also of the …

Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru
decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions …

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a
neurodegenerative disease characterized by loss of motor neurons. With conformation …

This study aims to provide an estimate of the number of individuals in the UK who may be
incubating variant Creutzfeldt‐Jakob disease and at risk of causing iatrogenic spread of the …

Structures of the infectious form of prion protein (eg PrP Sc or PrP-Scrapie) remain poorly
defined. The prevalent structural models of PrP Sc retain most of the native α-helices of the …

Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function to
proteins that contain them and cause at least nine neurological disorders. The basis for this …

Mutations in copper/zinc superoxide dismutase (SOD1) are causative for dominantly
inherited amyotrophic lateral sclerosis (ALS). Despite high variability in biochemical …

Nosologically, transmissible spongiform encephalopathies (TSE or prion diseases) should
be grouped with other neurodegenerative disorders such as Alzheimer's and Parkinson's …