Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

Ischemia-reperfusion (IR) injury is central to the pathology of major cardiovascular diseases,
such as stroke and myocardial infarction. IR injury is mediated by several factors including …

Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

Acute kidney injury (AKI) has been widely recognized as an important risk factor for the
occurrence and development of chronic kidney disease (CKD). Even milder AKI has adverse …

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Misfolded proteins in the central nervous system can induce oxidative damage, which can
contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients …

Reactive oxygen species (ROS) are produced during oxidative metabolism in aerobic
organisms. Under normal conditions, ROS production and elimination are in a relatively …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …