Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection
Connexins are widely distributed proteins in the body that are crucially important for heart
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …
Nanovesicles derived from iron oxide nanoparticles–incorporated mesenchymal stem cells for cardiac repair
Because of poor engraftment and safety concerns regarding mesenchymal stem cell (MSC)
therapy, MSC-derived exosomes have emerged as an alternative cell-free therapy for …
therapy, MSC-derived exosomes have emerged as an alternative cell-free therapy for …
Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia–reperfusion injury
M Ruiz-Meana, A Rodríguez-Sinovas… - Cardiovascular …, 2008 - academic.oup.com
Connexins are transmembrane proteins whose best known function is to form gap junction
channels. Ventricular cardiomyocytes express the connexin isoform Cx43 and are rich in …
channels. Ventricular cardiomyocytes express the connexin isoform Cx43 and are rich in …
Early fetal hypoxia leads to growth restriction and myocardial thinning
M Ream, AM Ray, R Chandra… - American Journal of …, 2008 - journals.physiology.org
Hypoxia is necessary for fetal development; however, excess hypoxia is detrimental.
Hypoxia has been extensively studied in the near-term fetus, but less is known about earlier …
Hypoxia has been extensively studied in the near-term fetus, but less is known about earlier …
Acellular Cardiac Extracellular Matrix as a Scaffold for Tissue Engineering: In Vitro Cell Support, Remodeling, and Biocompatibility
We have developed an efficient decellularization process for the isolation of extracellular
matrix (ECM) from native cardiac tissue. The isolated ECM exhibited desirable mechanical …
matrix (ECM) from native cardiac tissue. The isolated ECM exhibited desirable mechanical …
A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient
After a myocardial infarction, the boundary between the injured, hypoxic tissue and the
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
[HTML][HTML] ElectroMap: high-throughput open-source software for analysis and mapping of cardiac electrophysiology
The ability to record and analyse electrical behaviour across the heart using optical and
electrode mapping has revolutionised cardiac research. However, wider uptake of these …
electrode mapping has revolutionised cardiac research. However, wider uptake of these …
[HTML][HTML] Hypoxia-induced alternative splicing in endothelial cells
Background Adaptation to low oxygen by changing gene expression is vitally important for
cell survival and tissue development. The sprouting of new blood vessels, initiated from …
cell survival and tissue development. The sprouting of new blood vessels, initiated from …
Gliotransmitters and cytokines in the control of blood-brain barrier permeability
ED Osipova… - Reviews in the …, 2018 - degruyter.com
The contribution of astrocytes and microglia to the regulation of neuroplasticity or
neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and …
neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and …
[HTML][HTML] In vitro model of ischemic heart failure using human induced pluripotent stem cell–derived cardiomyocytes
J Davis, A Chouman, J Creech, AM da Rocha… - JCI insight, 2021 - ncbi.nlm.nih.gov
Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) have been
used extensively to model inherited heart diseases, but hiPSC-CM models of ischemic heart …
used extensively to model inherited heart diseases, but hiPSC-CM models of ischemic heart …