Biomarkers, designs, and interpretations of resting‐state fMRI in translational pharmacological research: A review of state‐of‐the‐Art, challenges, and opportunities for …

N Khalili‐Mahani, SARB Rombouts… - Human brain …, 2017 - Wiley Online Library
A decade of research and development in resting‐state functional MRI (RSfMRI) has
opened new translational and clinical research frontiers. This review aims to bridge between …

MRI assessment of cerebral perfusion in clinical trials

X Wang, C Bishop, J O'Callaghan, A Gayhoor… - Drug Discovery …, 2023 - Elsevier
Highlights•Use of MRI perfusion imaging in clinical trials and as an alternative to other
imaging modalities.•Detailed description of imaging procedures, best practices in clinical …

Calibration of arterial spin labeling data—potential pitfalls in post‐processing

J Pinto, MA Chappell, TW Okell… - Magnetic resonance …, 2020 - Wiley Online Library
Purpose To assess the impact of the different post‐processing options in the calibration of
arterial spin labeling (ASL) data on perfusion quantification and its reproducibility. Theory …

Comparison of arterial spin labeling registration strategies in the multi‐center GENetic frontotemporal dementia initiative (GENFI)

HJMM Mutsaerts, J Petr, DL Thomas… - Journal of Magnetic …, 2018 - Wiley Online Library
Purpose To compare registration strategies to align arterial spin labeling (ASL) with 3D T1‐
weighted (T1w) images, with the goal of reducing the between‐subject variability of cerebral …

[HTML][HTML] Microvascular impairment in patients with cerebral small vessel disease assessed with arterial spin labeling magnetic resonance imaging: a pilot study

K Neumann, M Günther, E Düzel… - Frontiers in aging …, 2022 - frontiersin.org
In this pilot study, we investigated microvascular impairment in patients with cerebral small
vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance …

[HTML][HTML] Short-term apparent brain tissue changes are contributed by cerebral blood flow alterations

Q Ge, W Peng, J Zhang, X Weng, Y Zhang, T Liu… - PloS one, 2017 - journals.plos.org
Structural MRI (sMRI)-identified tissue “growth” after neuropsychological training has been
reported in many studies but the origins of those apparent tissue changes (ATC) still remain …

Assessment of cerebral blood perfusion reserve with acetazolamide using 3D spiral ASL MRI: preliminary experience in pediatric patients

HH Hu, Z Li, AL Pokorney, JM Chia, N Stefani… - Magnetic resonance …, 2017 - Elsevier
Purpose To demonstrate the clinical feasibility of a new non-Cartesian cylindrically-
distributed spiral 3D pseudo-continuous arterial spin labeling (pCASL) magnetic resonance …

[HTML][HTML] Reliability and reproducibility of Hadamard encoded pseudo-continuous arterial spin labeling in healthy elderly

K Neumann, M Schidlowski, M Günther… - Frontiers in …, 2021 - frontiersin.org
The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured
with arterial spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable …

Addressing multi-centre image registration of 3T arterial spin labeling images from the GENetic Frontotemporal dementia Initiative (GENFI)

HJ Mutsaerts, DL Thomas, J Petr… - ISMRM 24th Annual …, 2016 - archive.ismrm.org
One obstacle in multi-centre arterial spin labeling (ASL) studies is the variability attributed to
differences between vendor-or site-specific ASL implementations. This multi-centre study …

Alzheimer's Disease Clinical Trials: What Have We Learned From Magnetic Resonance Imaging

S By, A Kahl, PM Cogswell - Journal of Magnetic Resonance Imaging - Wiley Online Library
Alzheimer's disease (AD) is the leading cause of cognitive impairment and dementia
worldwide with rising prevalence, incidence and mortality. Despite many decades of …