F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …

Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the
setting of insulin resistance. The current evidence suggests that genetic predisposition, and …

The objective of this study was to determine the optimal conditions under which to assess
glucose tolerance in chow-and high-fat-fed C57BL/6J mice. Mice were fed either chow or …

Inadequate β-cell mass can lead to insulin insufficiency and diabetes. During times of
prolonged metabolic demand for insulin, the endocrine pancreas can respond by increasing …

The treatment of diabetes mellitus represents one of the greatest medical challenges of our
era. Diabetes results from a deficiency or functional impairment of insulin-producing β cells …

OBJECTIVE The aim of this study was to elucidate whether age plays a role in the
expansion or regeneration of β-cell mass. RESEARCH DESIGN AND METHODS We …

A major goal in diabetes research is to find ways to enhance the mass and function of insulin
secreting β-cells in the endocrine pancreas to prevent and/or delay the onset or even …

Adult pancreatic β cells can replicate during growth and after injury to maintain glucose
homeostasis. Here, we report that β cells deficient in Dnmt1, an enzyme that propagates …

Pancreatic β cells secrete insulin in response to postprandial increases in glucose levels to
prevent hyperglycemia and inhibit insulin secretion under fasting conditions to protect …

Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental
challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase …