Orexins, or hypocretins, are excitatory neuropeptides involved in the regulation of feeding
behavior and the sleep and wakefulness states. Since their discovery, several lines of …

The orexin peptides (orexin A, orexin B) and their receptors (orexin receptor type 1, orexin
receptor type 2) are involved in multiple physiological processes such as the regulation of …

The hypothalamic neuropeptides orexin A and B (hypocretin 1 and 2) are important
homeostatic mediators of central control of energy metabolism and maintenance of …

Ingested nutrients are proposed to control mammalian behavior by modulating the activity of
hypothalamic orexin/hypocretin neurons (HONs). Previous in vitro studies showed that …

It has been proposed that binge eating reflects a pathological compulsion driven by the
“addictive” properties of foods. Proponents of this argument highlight the large degree of …

The lateral hypothalamus is critical for the control of ingestive behavior and spontaneous
physical activity (SPA), as lesion or stimulation of this region alters these behaviors …

Sitting too much kills. Epidemiological, physiological and molecular data suggest that
sedentary lifestyle can explain, in part, how modernity is associated with obesity, more than …

Typical body weight changes are known to occur in Parkinson's disease (PD). Weight loss
has been reported in early stages as well as in advanced disease and malnutrition may …

Results: Activation of orexin resulted in increases in SPA in male and female mice, and was
accompanied by increases in energy expenditure without changes in overall chow intake …

In patients with schizophrenia, insomnia is a common yet often overlooked comorbidity. With
sleep disturbances inextricably linked to increased severity of schizophrenia and worsening …