MLL-rearranged leukemias—an update on science and clinical approaches
AC Winters, KM Bernt - Frontiers in pediatrics, 2017 - frontiersin.org
The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins
Abstract Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important
transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master …
transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master …
Therapeutic targeting of MLL degradation pathways in MLL-rearranged leukemia
Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner
genes result in aggressive leukemia with dismal outcomes. Despite similar expression at the …
genes result in aggressive leukemia with dismal outcomes. Despite similar expression at the …
Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/CCdh1 complex
X Gong, S Wang, Q Yu, M Wang, F Ge, S Li, X Yu - Science Advances, 2023 - science.org
H3K4 trimethylation (H3K4me3) is a conserved histone modification catalyzed by histone
methyltransferase Set1, and its dysregulation is associated with pathologies. Here, we show …
methyltransferase Set1, and its dysregulation is associated with pathologies. Here, we show …
[HTML][HTML] Diverse functions of PHD fingers of the MLL/KMT2 subfamily
M Ali, RA Hom, W Blakeslee, L Ikenouye… - … Et Biophysica Acta (BBA …, 2014 - Elsevier
Five members of the KMT2 family of lysine methyltransferases, originally named the mixed
lineage leukemia (MLL1-5) proteins, regulate gene expression during embryogenesis and …
lineage leukemia (MLL1-5) proteins, regulate gene expression during embryogenesis and …
An MLL-dependent network sustains hematopoiesis
EL Artinger, BP Mishra, KM Zaffuto… - Proceedings of the …, 2013 - National Acad Sciences
The histone methyltransferase Mixed Lineage Leukemia (MLL) is essential to maintain
hematopoietic stem cells and is a leukemia protooncogene. Although clustered homeobox …
hematopoietic stem cells and is a leukemia protooncogene. Although clustered homeobox …
[HTML][HTML] Histone methylation in pancreatic cancer and its clinical implications
XY Liu, CH Guo, ZY Xi, XQ Xu, QY Zhao… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) is an aggressive human cancer. Appropriate methods for the
diagnosis and treatment of PC have not been found at the genetic level, thus making …
diagnosis and treatment of PC have not been found at the genetic level, thus making …
Non-histone binding functions of PHD fingers
N Gaurav, TG Kutateladze - Trends in Biochemical Sciences, 2023 - cell.com
Plant homeodomain (PHD) fingers comprise a large and well-established family of
epigenetic readers that recognize histone H3. A typical PHD finger binds to the unmodified …
epigenetic readers that recognize histone H3. A typical PHD finger binds to the unmodified …
The molecular functions of common and atypical MLL fusion protein complexes
S Takahashi, A Yokoyama - Biochimica Et Biophysica Acta (BBA)-Gene …, 2020 - Elsevier
Mixed-lineage leukemia (MLL) fuses with a variety of partners to produce a functionally
altered MLL complex that is not expressed in normal cells, which transforms normal …
altered MLL complex that is not expressed in normal cells, which transforms normal …
AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion-and AEP-dependent transcription
H Okuda, A Kanai, S Ito, H Matsui… - Nature communications, 2015 - nature.com
Gene rearrangements generate MLL fusion genes, which can lead to aggressive leukemia.
In most cases, MLL fuses with a gene encoding a component of the AEP (AF4 family/ENL …
In most cases, MLL fuses with a gene encoding a component of the AEP (AF4 family/ENL …