The assembly, regulation and function of the mitochondrial respiratory chain
I Vercellino, LA Sazanov - Nature reviews Molecular cell biology, 2022 - nature.com
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …
comprises five enzymatic complexes and two mobile electron carriers that work in a …
Mechanisms of mitochondrial respiratory adaptation
CF Bennett, P Latorre-Muro, P Puigserver - Nature Reviews Molecular …, 2022 - nature.com
Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …
maintain cell and organismal fitness and survival in the changing environment by adjusting …
[HTML][HTML] Generation of reactive oxygen species by mitochondria
P Hernansanz-Agustín, JA Enríquez - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are series of chemical products originated from one or
several electron reductions of oxygen. ROS are involved in physiology and disease and can …
several electron reductions of oxygen. ROS are involved in physiology and disease and can …
Mitochondrial disorders of the OXPHOS system
E Fernandez‐Vizarra, M Zeviani - FEBS letters, 2021 - Wiley Online Library
Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …
Structure and assembly of the mammalian mitochondrial supercomplex CIII2CIV
I Vercellino, LA Sazanov - Nature, 2021 - nature.com
The enzymes of the mitochondrial electron transport chain are key players of cell
metabolism. Despite being active when isolated, in vivo they associate into supercomplexes …
metabolism. Despite being active when isolated, in vivo they associate into supercomplexes …
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch
E Fernandez-Vizarra, S Lopez-Calcerrada… - Cell Metabolism, 2022 - cell.com
The structural and functional organization of the mitochondrial respiratory chain (MRC)
remains intensely debated. Here, we show the co-existence of two separate MRC …
remains intensely debated. Here, we show the co-existence of two separate MRC …
Regulation and functional role of the electron transport chain supercomplexes
S Cogliati, JL Cabrera-Alarcón… - Biochemical Society …, 2021 - portlandpress.com
Mitochondria are one of the most exhaustively investigated organelles in the cell and most
attention has been paid to the components of the mitochondrial electron transport chain …
attention has been paid to the components of the mitochondrial electron transport chain …
Respiratory supercomplexes enhance electron transport by decreasing cytochrome c diffusion distance
J Berndtsson, A Kohler, S Rathore, L Marin‐Buera… - EMBO …, 2020 - embopress.org
Respiratory chains are crucial for cellular energy conversion and consist of multi‐subunit
complexes that can assemble into supercomplexes. These structures have been intensively …
complexes that can assemble into supercomplexes. These structures have been intensively …
Mitochondrial respiratory chain supercomplexes: from structure to function
S Guan, L Zhao, R Peng - International Journal of Molecular Sciences, 2022 - mdpi.com
Mitochondrial oxidative phospho rylation, the center of cellular metabolism, is pivotal for the
energy production in eukaryotes. Mitochondrial oxidative phosphorylation relies on the …
energy production in eukaryotes. Mitochondrial oxidative phosphorylation relies on the …
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2
K Chella Krishnan, L Vergnes, R Acín-Pérez… - Nature …, 2021 - nature.com
We have previously suggested a central role for mitochondria in the observed sex
differences in metabolic traits. However, the mechanisms by which sex differences affect …
differences in metabolic traits. However, the mechanisms by which sex differences affect …