Synaptic plasticity configures interactions between neurons and is therefore likely to be a
primary driver of behavioral learning and development. How this microscopic-macroscopic …

At the simplest level, neurons are structured to integrate synaptic input and perform
computational transforms on that input, converting it into an action potential (AP) code. This …

Homeostatic plasticity maintains the stability of functional brain networks. The axon initial
segment (AIS), where action potentials start, undergoes dynamic adjustment to exert …

The canonical view of neuronal function is that inputs are received by dendrites and somata,
become integrated in the somatodendritic compartment and upon reaching a sufficient …

The enhanced cognitive abilities characterizing the human species result from specialized
features of neurons and circuits. Here, we report that the hominid-specific gene LRRC37B …

Early life stress is thought to be a risk factor for emotional disorders, particularly depression
and anxiety. Although the excitation/inhibition (E/I) imbalance has been implicated in …

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS.
Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic …

Dendritic spines are highly dynamic neuronal compartments that control the synaptic
transmission between neurons. Spines form ultrastructural units, coupling synaptic contact …

Dysregulated neuronal excitability is a hallmark of amyotrophic lateral sclerosis (ALS). We
sought to investigate how functional changes to the axon initial segment (AIS), the site of …

Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability
to adapt action potential output to changes in network activity. Action potential initiation at …