Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the
gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals …

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …

In the early 2000s, caspase-1, an important molecule that has been shown to be involved in
the regulation of inflammation, cell survival and diseases, was given a new function …

Osteoarthritis (OA) is a common degenerative joint disease, mainly presented by the
deterioration of articular cartilage. Amounts of data demonstrated this deterioration is …

Millions of patients are suffering from ischemic stroke, it is urgent to figure out the
pathogenesis of cerebral ischemia–reperfusion (I/R) injury in order to find an effective cure …

The activation of the nucleotide oligomerization domain (NOD)‐like receptor (NLR) family,
pyrin domain‐containing protein 3 (NLRP3) inflammasome is related to the pathogenesis of …

The NLRP3 inflammasome is a critical component of innate immunity involved in the
pathophysiology of various inflammatory diseases. In this study, we designed and …

Aberrant activation of NLRP3 inflammasome has been implicated in a variety of human
inflammatory diseases, but currently, no pharmacological NLRP3 inhibitor has been …

Ischemic stroke is the second leading cause of death worldwide with limited medications
and neuroinflammation was recognized as a critical player in the progression of stroke, but …