The Melanocortin System: a promising target for the development of new antidepressant Drugs

DD Markov, OV Dolotov, IA Grivennikov - International Journal of …, 2023 - mdpi.com
Major depression is one of the most prevalent mental disorders, causing significant human
suffering and socioeconomic loss. Since conventional antidepressants are not sufficiently …

Stress and the CRH System, Norepinephrine, Depression, and Type 2 Diabetes

M Perrelli, P Goparaju, TT Postolache… - Biomedicines, 2024 - mdpi.com
Major depressive disorder (MDD) increases the risk of type 2 diabetes (T2D) by 60% in
untreated patients, and hypercortisolism is common in MDD as well as in some patients with …

Familial Linkage and Association of the NR3C1 Gene with Type 2 Diabetes and Depression Comorbidity

M Amin, S Syed, R Wu, TT Postolache… - International journal of …, 2022 - mdpi.com
Impairment in the hypothalamic-pituitary-adrenal (HPA) axis and cortisol pathway may be
major contributing factors to the common pathogenesis of major depressive disorders (MDD) …

The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families

R Wu, C Gragnoli - Journal of Ovarian Research, 2024 - Springer
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder occurring in
women of reproductive age. The disease is caused by a complex interplay of genetic and …

[HTML][HTML] Novel linkage and association of the mineralocorticoid receptor gene (NR3C2) with familial type 2 diabetes and depression and their comorbidity

M Amin, S Syed, R Wu, TT Postolache… - Aspects of Molecular …, 2023 - Elsevier
Introduction The mineralocorticoid receptor gene (NR3C2) appears to modulate stress and
cognitive performance in patients with major depressive disorder (MDD). In addition …

Nivel de ansiedad, depresión y estrés en pacientes con diabetes mellitus tipo 2 en la región de La Libertad

VH Burgos Cerdan - 2023 - repositorio.ucv.edu.pe
El presente estudio pretende evaluar el nivel de ansiedad, depresión y estrés en pacientes
con diabetes mellitus tipo 2 en el centro de salud casa Grande. El estudio es No …

[PDF][PDF] Aspects of Molecular Medicine

M Amin, S Syed, R Wu, TT Postolache, C Gragnoli - researchgate.net
Background: Type 2 diabetes mellitus (T2D) stands as one of the most prevalent chronic
diseases globally, posing substantial health and economic burdens on society. Within the …

[PDF][PDF] THE ROLE OF MELANOCORTIN 1 RECEPTOR IN THE REGULATION OF CHOLESTEROL AND FATTY ACID METABOLISM IN THE LIVER

K Thapa - utupub.fi
The melanocortins are a family of neuropeptide hormones consisting of
melanocytestimulating hormones, α-, β-, and γ-MSH, and adrenocorticotropic hormone …