Background Climate change presents an imminent threat to almost all biological systems
across the globe. In recent years there have been a series of studies showing how changes …

Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …

Objective To report the global, regional, and national burden of chronic obstructive
pulmonary disease (COPD) and its attributable risk factors between 1990 and 2019, by age …

Background Previous attempts to characterise the burden of chronic respiratory diseases
have focused only on specific disease conditions, such as chronic obstructive pulmonary …

Summary Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring
together all available epidemiological data using a coherent measurement framework …

Chronic respiratory diseases are among the most common non-communicable diseases
worldwide, largely due to the ubiquity of noxious environmental, occupational, and …

The rise in the measured prevalence of autism has been accompanied by much new
research and research investment internationally. This study sought to establish whether the …

Summary Background In 2008, 2· 45 million people were diagnosed with cancer and 1· 23
million died because of cancer in the 27 countries of the European Union (EU). We aimed to …

Abstract Background and Aims Cardiovascular disease (CVD) impacts significantly health
and social care systems as well as society through premature mortality and disability, with …

Importance Medical research is a prerequisite of clinical advances, while health service
research supports improved delivery, access, and cost. Few previous analyses have …