The role of interleukin-8 in lung inflammation and injury: implications for the management of COVID-19 and hyperinflammatory acute respiratory distress syndrome

MC Cesta, M Zippoli, C Marsiglia, EM Gavioli… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus—2 (SARS CoV-2) has resulted in the
global spread of Coronavirus Disease 2019 (COVID-19) and an increase in complications …

COVID‐19 immunopathology: from acute diseases to chronic sequelae

M Arish, W Qian, H Narasimhan… - Journal of medical …, 2023 - Wiley Online Library
The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung
as a primary affected organ, which is also a critical site of immune cell activation by severe …

[HTML][HTML] Mild COVID-19 imprints a long-term inflammatory eicosanoid-and chemokine memory in monocyte-derived macrophages

S Bohnacker, F Hartung, F Henkel, A Quaranta… - Mucosal …, 2022 - Elsevier
Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of …

Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

P Chen, M Wu, Y He, B Jiang, ML He - Signal Transduction and …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …

Explanatory predictive model for COVID-19 severity risk employing machine learning, shapley addition, and LIME

M Laatifi, S Douzi, H Ezzine, CE Asry, A Naya… - Scientific Reports, 2023 - nature.com
The rapid spread of SARS-CoV-2 threatens global public health and impedes the operation
of healthcare systems. Several studies have been conducted to confirm SARS-CoV-2 …

The potential importance of CXCL1 in the physiological state and in noncancer diseases of the cardiovascular system, respiratory system and skin

J Korbecki, A Maruszewska, M Bosiacki… - International Journal of …, 2022 - mdpi.com
In this paper, we present a literature review of the role of CXC motif chemokine ligand 1
(CXCL1) in physiology, and in selected major non-cancer diseases of the cardiovascular …

Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

B Malengier-Devlies, J Filtjens, K Ahmadzadeh… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterised by a broad spectrum of clinical and pathological features. Natural
killer (NK) cells play an important role in innate immune responses to viral infections. Here …

Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load

DJ Eddins, J Yang, A Kosters, VD Giacalone… - Blood …, 2023 - ashpublications.org
Troubling disparities in COVID-19–associated mortality emerged early, with nearly 70% of
deaths confined to Black/African American (AA) patients in some areas. However, targeted …

[HTML][HTML] Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID …

AM Chaves-Filho, O Braniff, A Angelova, Y Deng… - Brain Research …, 2023 - Elsevier
After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …

Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs

M Aslani, SS Mortazavi-Jahromi, A Mirshafiey - International …, 2021 - Elsevier
Abstract SARS-CoV-2, as the causative agent of COVID-19, is an enveloped positives-sense
single-stranded RNA virus that belongs to the Beta-CoVs sub-family. A sophisticated hyper …