It is more effective to maintain good health than to regain it after losing it. This work focuses
on the biochemical defense mechanisms against free radicals and their role in building and …

Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions
leading to neuronal death, including programs of regulated death, are commonly viewed as …

Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure
through direct interactions of radiation with target macromolecules or via products of water …

The disulfide bond (− S− S−) is an extremely valuable functional group in a variety of
chemical and biological agents that display potent reactivity or biological activities (eg …

Glutathione (γ-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight
thiol, and GSH/glutathione disulfide is the major redox couple in animal cells. The synthesis …

In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular
endothelium, and kidney arise from chronic elevations of glucose and possibly other …

Polyphenols are wide variety of compounds that occur in fruits and vegetables, wine, tea,
extra virgin olive oil, chocolate and other cocoa products. Several polyphenols have been …

Hydrogen sulfide (H2S) is a synaptic modulator as well as a neuroprotectant in the brain. We
recently showed that H2S protects neurons from oxidative stress by increasing the levels of …

The glutathione (GSH) content of cancer cells is particularly relevant in regulating mutagenic
mechanisms, DNA synthesis, growth, and multidrug and radiation resistance. In malignant …

We present the design, synthesis, spectroscopic properties, and biological evaluation of a
single galactose-appended naphthalimide (1). Probe 1 is a multifunctional molecule that …