Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt
and respond to them. PM invaginations named caveolae, with a specific protein and lipid …

Excitation-contraction coupling requires a highly specialized membrane structure, the triad,
composed of a plasma membrane invagination, the T-tubule, surrounded by two …

Importance Immune-mediated rippling muscle disease (iRMD) is a rare myopathy
characterized by wavelike muscle contractions (rippling) and percussion-or stretch-induced …

Acute Lung Injury (ALI) is characterized by widespread inflammation which in its severe
form, Acute Respiratory Distress Syndrome (ARDS), leads to compromise in respiration …

A transverse-tubule (T-tubule) is an invagination of the plasma membrane penetrating deep
into muscle cells. An extensive membrane network of T-tubules is crucial for rapid and …

Plasma membrane rupture can result in catastrophic cell death. The skeletal muscle fiber
plasma membrane, the sarcolemma, provides an extreme example of a membrane subject …

An emerging alternative to conventional animal models in toxicology research is the
zebrafish. Their accelerated development, regenerative capacity, transparent physical …

Amphiphysin-2 is a ubiquitously expressed protein also known as bridging integrator 1
(BIN1), playing a critical role in membrane remodeling, trafficking, and cytoskeleton …

Truncation of the protein-protein interaction SH3 domain of the membrane remodeling
Bridging Integrator 1 (BIN1, Amphiphysin 2) protein leads to centronuclear myopathy. Here …