[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
[HTML][HTML] The role of PI3K/AKT/mTOR signaling in hepatocellular carcinoma metabolism
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
[HTML][HTML] mTOR-mediated regulation of immune responses in cancer and tumor microenvironment
The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …
Charge‐reversal polymer nano‐modulators for photodynamic immunotherapy of cancer
Nanomedicine can regulate the balance between cytotoxic T lymphocytes (CTLs) and
suppressive regulatory T lymphocytes (Tregs), which however has been rarely exploited for …
suppressive regulatory T lymphocytes (Tregs), which however has been rarely exploited for …
[PDF][PDF] Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates
The rule of 5 (Ro5) is a set of in silico guidelines applied to drug discovery to prioritize
compounds with an increased likelihood of high oral absorption. It has been influential in …
compounds with an increased likelihood of high oral absorption. It has been influential in …
Glioblastoma: Current status, emerging targets, and recent advances
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …
population of genetically unstable and highly infiltrative cells that are resistant to …
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition
Loss of function in tumor suppressor genes is commonly associated with the
onset/progression of cancer and treatment resistance. The p53 tumor suppressor gene, a …
onset/progression of cancer and treatment resistance. The p53 tumor suppressor gene, a …
A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval
NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
The rising outbreak of SARS-CoV-2 continues to unfold all over the world. The development
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
[HTML][HTML] Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies
The large coding potential of vaccinia virus (VV) vectors is a defining feature. However,
limited regulatory switches are available to control viral replication as well as timing and …
limited regulatory switches are available to control viral replication as well as timing and …
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug
The rapid development of new anticancer drugs that are safe and effective is a common goal
shared by basic scientists, clinicians and patients. The current review discusses one such …
shared by basic scientists, clinicians and patients. The current review discusses one such …