Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …

A variety of acute brain insults can induce epileptogenesis, a complex process that results in
acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis …

Background Traumatic brain injury (TBI) is a leading cause of disabilities resulting from
cognitive and neurological deficits, as well as psychological disorders. Only recently …

Previous neuroimaging studies in rodents investigated effects of the controlled cortical
impact (CCI) model of traumatic brain injury (TBI) within one-month post-TBI. This study …

A biomarker is a characteristic that can be objectively measured as an indicator of normal
biologic processes, pathogenic processes, or responses to an exposure or intervention …

Abstract Development of epilepsy or epileptogenesis promotes recurrent seizures. As of
today, there are no effective prophylactic therapies to prevent the onset of epilepsy …

Objectives: We investigated whether seizure susceptibility increases over weeks–months
after experimental traumatic brain injury (TBI), and whether seizure susceptibility in rats …

Mechanisms initiated by traumatic brain injury (TBI), leading to the development of
progressive secondary injury are poorly understood. MicroRNAs (miRNAs) have a proposed …

Na+ sensitivity is a unique feature of Na+-activated K+ (KNa) channels, making them
naturally suited to counter a sudden influx in Na+ ions. As such, it has long been suggested …

Prognostic biomarkers for post-injury outcome are necessary for the development of
neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We …