Overview of direct-acting antiviral drugs and drug resistance of hepatitis C virus
DK Li, RT Chung - Hepatitis C Virus Protocols, 2019 - Springer
The advent of direct-acting antivirals (DAAs) has brought about a sudden renaissance in the
treatment of chronic hepatitis C virus (HCV) infection with SVR rates now routinely> 90 …
treatment of chronic hepatitis C virus (HCV) infection with SVR rates now routinely> 90 …
Drug repurposing for new, efficient, broad spectrum antivirals
M García-Serradilla, C Risco, B Pacheco - Virus research, 2019 - Elsevier
Emerging viruses are a major threat to human health. Recent outbreaks have emphasized
the urgent need for new antiviral treatments. For several pathogenic viruses, considerable …
the urgent need for new antiviral treatments. For several pathogenic viruses, considerable …
Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation
A Latanova, E Starodubova, V Karpov - Viruses, 2022 - mdpi.com
Members of the Flaviviridae family are posing a significant threat to human health
worldwide. Many flaviviruses are capable of inducing severe inflammation in humans …
worldwide. Many flaviviruses are capable of inducing severe inflammation in humans …
Resistance mechanisms in hepatitis C virus: implications for direct-acting antiviral use
S Bagaglio, C Uberti-Foppa, G Morsica - Drugs, 2017 - Springer
Multiple direct-acting antiviral (DAA)-based regimens are currently approved that provide
one or more interferon-free treatment options for hepatitis C virus (HCV) genotypes (G) 1–6 …
one or more interferon-free treatment options for hepatitis C virus (HCV) genotypes (G) 1–6 …
Signals involved in regulation of hepatitis C virus RNA genome translation and replication
M Niepmann, LA Shalamova, GK Gerresheim… - Frontiers in …, 2018 - frontiersin.org
Hepatitis C virus (HCV) preferentially replicates in the human liver and frequently causes
chronic infection, often leading to cirrhosis and liver cancer. HCV is an enveloped virus …
chronic infection, often leading to cirrhosis and liver cancer. HCV is an enveloped virus …
Emergence and persistence of resistance-associated substitutions in HCV GT3 patients failing direct-acting antivirals
Background: The hepatitis C virus has a high mutation rate, which results in the emergence
of resistance-associated substitutions (RASs). Despite direct-acting antivirals (DAAs) efforts …
of resistance-associated substitutions (RASs). Despite direct-acting antivirals (DAAs) efforts …
Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
C Zitzmann, C Dächert, B Schmid… - PLoS computational …, 2023 - journals.plos.org
Plus-strand RNA viruses are the largest group of viruses. Many are human pathogens that
inflict a socio-economic burden. Interestingly, plus-strand RNA viruses share remarkable …
inflict a socio-economic burden. Interestingly, plus-strand RNA viruses share remarkable …
Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus
ME Soria, J Gregori, Q Chen, D García-Cehic… - BMC Infectious …, 2018 - Springer
Background Despite the high sustained virological response rates achieved with current
directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5–10% of …
directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5–10% of …
[HTML][HTML] Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance
M Jiménez-Pérez, R González-Grande… - World Journal of …, 2016 - ncbi.nlm.nih.gov
The use of direct-acting antivirals (DAAs) to treat chronic hepatitis C has resulted in a
significant increase in rates of sustained viral response (around 90%-95%) as compared …
significant increase in rates of sustained viral response (around 90%-95%) as compared …
Barrier-independent, fitness-associated differences in sofosbuvir efficacy against hepatitis C virus
Sofosbuvir displays a high phenotypic barrier to resistance, and it is a component of several
combination therapies for hepatitis C virus (HCV) infections. HCV fitness can be a …
combination therapies for hepatitis C virus (HCV) infections. HCV fitness can be a …