[HTML][HTML] Development of NK cell-based cancer immunotherapies through receptor engineering
A Page, N Chuvin, J Valladeau-Guilemond… - Cellular & Molecular …, 2024 - nature.com
Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field
of cancer treatment. Early clinical trials have shown promising outcomes, alongside …
of cancer treatment. Early clinical trials have shown promising outcomes, alongside …
Applications of CRISPR technology in cellular immunotherapy
CRISPR technology has transformed multiple fields, including cancer and immunology.
CRISPR‐based gene editing and screening empowers direct genomic manipulation of …
CRISPR‐based gene editing and screening empowers direct genomic manipulation of …
Base-editing mutagenesis maps alleles to tune human T cell functions
CRISPR-enabled screening is a powerful tool for the discovery of genes that control T cell
function and has nominated candidate targets for immunotherapies,,,,–. However, new …
function and has nominated candidate targets for immunotherapies,,,,–. However, new …
[HTML][HTML] Large-scale manufacturing of base-edited chimeric antigen receptor T cells
R Woodruff, F Parekh, K Lamb, L Mekkaoui… - … Therapy-Methods & …, 2023 - cell.com
Base editing is a revolutionary gene-editing technique enabling the introduction of point
mutations into the genome without generating detrimental DNA double-stranded breaks …
mutations into the genome without generating detrimental DNA double-stranded breaks …
[HTML][HTML] Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modeling
M Ravichandran, D Maddalo - Frontiers in Genetics, 2023 - frontiersin.org
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated protein 9 (Cas9)(CRISPR/Cas9) system is a powerful tool that enables precise …
associated protein 9 (Cas9)(CRISPR/Cas9) system is a powerful tool that enables precise …
Development of multiplexed orthogonal base editor (MOBE) systems
Base editors (BEs) enable efficient, programmable installation of point mutations while
avoiding the use of double-strand breaks. Simultaneous application of two or more different …
avoiding the use of double-strand breaks. Simultaneous application of two or more different …
Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens
Single-nucleotide variants (SNVs) in key T cell genes can drive clinical pathologies and
could be repurposed to improve cellular cancer immunotherapies. Here, we perform …
could be repurposed to improve cellular cancer immunotherapies. Here, we perform …
[HTML][HTML] Allogeneic CAR-T cells with of HLA-A/B and TRAC disruption exhibit promising antitumor capacity against B cell malignancies
X Chen, B Tan, H Xing, X Zhao, Y Ping, Z Zhang… - Cancer Immunology …, 2024 - Springer
Background Although chimeric antigen receptor T (CAR-T) cells have been proven to be an
effective way of treating B cell malignancies, a lot of patients could not benefit from it …
effective way of treating B cell malignancies, a lot of patients could not benefit from it …
Integration of ζ-deficient CARs into the CD3ζ gene conveys potent cytotoxicity in T and NK cells
J Kath, C Franke, V Drosdek, W Du, V Glaser… - Blood, 2024 - ashpublications.org
Chimeric antigen receptor (CAR)-redirected immune cells hold significant therapeutic
potential for oncology, autoimmune diseases, transplant medicine, and infections. All …
potential for oncology, autoimmune diseases, transplant medicine, and infections. All …
Altered cancer metabolism and implications for next-generation CAR T-cell therapies
This review critically examines the evolving landscape of chimeric antigen receptor (CAR) T-
cell therapy in treating solid tumors, with a particular focus on the metabolic challenges …
cell therapy in treating solid tumors, with a particular focus on the metabolic challenges …