Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors

AP Klein - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Pancreatic cancer is a leading cause of cancer death worldwide and its global burden has
more than doubled over the past 25 years. The highest incidence regions for pancreatic …

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data

AA Connor, S Gallinger - Nature Reviews Cancer, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …

[HTML][HTML] A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories

D Placido, B Yuan, JX Hjaltelin, C Zheng, AD Haue… - Nature medicine, 2023 - nature.com
Pancreatic cancer is an aggressive disease that typically presents late with poor outcomes,
indicating a pronounced need for early detection. In this study, we applied artificial …

Pancreatic cancer: a review of risk factors, diagnosis, and treatment

ZY Zhao, W Liu - Technology in cancer research & treatment, 2020 - journals.sagepub.com
This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of
pancreatic cancer, and aims to promote further research on this under-studied malignant …

Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) …

M Goggins, KA Overbeek, R Brand, S Syngal… - Gut, 2020 - gut.bmj.com
Background and aim The International Cancer of the Pancreas Screening Consortium met in
2018 to update its consensus recommendations for the management of individuals with …

Pancreatic cancer: changing epidemiology and new approaches to risk assessment, early detection, and prevention

EM Stoffel, RE Brand, M Goggins - Gastroenterology, 2023 - Elsevier
Pancreatic cancer usually results in poor survival with limited options for treatment, as most
affected individuals present with advanced disease. Early detection of preinvasive …

[HTML][HTML] Artificial intelligence and early detection of pancreatic cancer: 2020 summative review

B Kenner, ST Chari, D Kelsen, DS Klimstra, SJ Pandol… - Pancreas, 2021 - journals.lww.com
Despite considerable research efforts, pancreatic cancer is associated with a dire prognosis
and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly …

Genotype imputation from large reference panels

S Das, GR Abecasis, BL Browning - Annual review of genomics …, 2018 - annualreviews.org
Genotype imputation has become a standard tool in genome-wide association studies
because it enables researchers to inexpensively approximate whole-genome sequence …

[HTML][HTML] Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction

L Kachuri, RE Graff, K Smith-Byrne, TJ Meyers… - Nature …, 2020 - nature.com
Cancer risk is determined by a complex interplay of environmental and heritable factors.
Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be …

Genome-wide association study of bladder cancer reveals new biological and translational insights

S Koutros, LA Kiemeney, PP Choudhury, RL Milne… - European urology, 2023 - Elsevier
Background Genomic regions identified by genome-wide association studies (GWAS) for
bladder cancer risk provide new insights into etiology. Objective To identify new …