The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …

Neural stem cells (NSCs) provide promising approaches for investigating embryonic
neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and …

INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present …

Abstract Calcium (Ca 2+) signaling has essential roles in the development of the nervous
system from neural induction to the proliferation, migration, and differentiation of neural cells …

The mammalian TET enzymes catalyze DNA demethylation. While they have been intensely
studied as major epigenetic regulators, little is known about their physiological roles and the …

The progression of cancer to metastatic disease is a major cause of death. We identified miR-
708 being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 …

Mushroom spine loss and calcium dyshomeostasis are early hallmark events of age-related
neurodegeneration, such as Alzheimer's disease (AD), that are connected with neuronal …

Neuronatin (NNAT) is a transmembrane protein in the endoplasmic reticulum involved in
metabolic regulation. It shares sequence homology with sarcolipin (SLN), which negatively …

TET-family dioxygenases catalyze conversion of 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC) and oxidized methylcytosines in DNA. Here, we show that …

Although the antitumor role of metformin has been widely reported, the molecular
mechanism of this biguanide agent in the inhibition of tumor progression remains unclear …