Mammalian cells have developed dedicated molecular mechanisms to tightly control
expression levels of their genes where the specific transcriptomic signature across all genes …

Optogenetics holds the promise of controlling biological processes with superb temporal
and spatial resolution at minimal perturbation. Although many of the light-reactive proteins …

Optogenetics is the genetic approach for controlling cellular processes with light. It provides
spatiotemporal, quantitative and reversible control over biological signaling and metabolic …

Under adverse conditions such as shade or elevated temperatures, cotyledon expansion is
reduced and hypocotyl growth is promoted to optimize plant architecture. The mechanisms …

The l-arabinose-responsive AraC and its cognate PBAD promoter underlie one of the most
often used chemically inducible prokaryotic gene expression systems in microbiology and …

Molecular glues and proteolysis targeting chimeras (PROTACs) have emerged as small-
molecule tools that selectively induce the degradation of a chosen protein and have shown …

Highlights•State-of the art approaches to implement optogenetics in mammals.•Application
principles of optogenetic strategies in freely moving animals.•All-optical approaches …

Increased control of biological growth and form is an essential gateway to transformative
medical advances. Repairing of birth defects, restoring lost or damaged organs, normalizing …

Synthetic biology is an established but ever-growing interdisciplinary field of research
currently revolutionizing biomedicine studies and the biotech industry. The engineering of …

The production of high‐quality recombinant proteins is critical to maintaining a continuous
supply of biopharmaceuticals, such as therapeutic antibodies. Engineering mammalian cell …