The immunobiology and pathogenesis of celiac disease
Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an
immunopathogenesis that is particularly well understood. The condition is characterized by …
immunopathogenesis that is particularly well understood. The condition is characterized by …
HLA variation and disease
Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …
HLA molecules have proven to be central to physiology, protective immunity and …
T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
T cells in celiac disease
Celiac disease is a human T cell–mediated autoimmune-like disorder caused by exposure
to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T …
to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T …
Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells
JD Ooi, J Petersen, YH Tan, M Huynh, ZJ Willett… - Nature, 2017 - nature.com
Susceptibility and protection against human autoimmune diseases, including type I
diabetes, multiple sclerosis, and Goodpasture disease, is associated with particular human …
diabetes, multiple sclerosis, and Goodpasture disease, is associated with particular human …
Variations in MHC class II antigen processing and presentation in health and disease
ER Unanue, V Turk, J Neefjes - Annual review of immunology, 2016 - annualreviews.org
MHC class II (MHC-II) molecules are critical in the control of many immune responses. They
are also involved in most autoimmune diseases and other pathologies. Here, we describe …
are also involved in most autoimmune diseases and other pathologies. Here, we describe …
[HTML][HTML] The Many Faces of CD4+ T Cells: Immunological and Structural Characteristics
As a major arm of the cellular immune response, CD4+ T cells are important in the control
and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral …
and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral …
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease
J Petersen, L Ciacchi, MT Tran, KL Loh… - Nature Structural & …, 2020 - nature.com
The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated
autoimmune disorders. HLA-DQ2. 5-mediated celiac disease (CeD) is triggered by the …
autoimmune disorders. HLA-DQ2. 5-mediated celiac disease (CeD) is triggered by the …
[HTML][HTML] Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease
Celiac disease is an autoimmune disorder in which ingestion of dietary gluten triggers an
immune reaction in the small intestine leading to destruction of the lining epithelium. Current …
immune reaction in the small intestine leading to destruction of the lining epithelium. Current …