Many essential physiological processes are controlled by calcium. To ensure reliability and
specificity, calcium signals are highly organized in time and space in the form of oscillations …

Cellular signaling operates in a noisy environment shaped by low molecular concentrations
and cellular heterogeneity. For calcium release through intracellular channels–one of the …

Calcium puffs are local Ca 2+ release events that arise from a cluster of inositol 1, 4, 5-
trisphosphate receptor channels (IP 3 Rs) and serve as a basic" building block" from which …

Neurotransmitter release from presynaptic terminals is primarily regulated by rapid Ca2+
influx through membrane-resident voltage-gated Ca2+ channels (VGCCs). Moreover …

Mechanically activated Piezo1 channels undergo transitions from closed to open-state in
response to pressure and other mechanical stimuli. However, the molecular details of these …

The purpose of this computational study was to investigate the possible role of voltage-gated
Ca 2+ channels in spontaneous Ca 2+ oscillations of astrocytes. By incorporating different …

Using deterministic-stochastic simulations we show that for intracellular calcium puffs the
mixing assumption for reactants does not hold within clusters of receptor channels …

Abstract Changes in cellular Ca 2+ concentration control a wide range of physiological
processes, from the subsecond release of synaptic neurotransmitters, to the regulation of …

Ca2+ is a fundamental intracellular signal that mediates a variety of disparate physiological
functions often in the same cell. Ca2+ signals span a wide range of spatial and temporal …

Amyloid beta (Aβ) oligomers associated with Alzheimer's disease (AD) form Ca2+-
permeable plasma membrane pores, leading to a disruption of the otherwise well-controlled …