While the Staudinger reaction has first been described a hundred years ago in 1919, the
ligation reaction became one of the most important and efficient bioconjugation techniques …

Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

The discovery of the first “living” radical polymerization by Otsu and co-workers (1) in 1982
heralded the start of a very exciting time for polymer chemists. Since then, a plethora of living …

The investigation of biological processes by chemical methods, commonly referred to as
chemical biology, often requires chemical access to biologically relevant macromolecules …

1.1 Aims This review updates our original review on the synthesis of glycoproteins.(1) Its
aims, therefore, are 2-fold: to highlight, first, key developments since 2002 and, second …

Bioconjugation via azide– Staudinger ligation : an overview - Chemical Society Reviews (RSC
Publishing) DOI:10.1039/C0CS00123F Royal Society of Chemistry View PDF VersionPrevious …

Enzyme catalysis is an inherently dynamic process. Binding and release of ligands is often
accompanied by conformational changes, both subtle and dramatic (reviewed more …

▪ Abstract Proteins have become accessible targets for chemical synthesis. The basic
strategy is to use native chemical ligation, Staudinger ligation, or other orthogonal chemical …

The review addresses the functional and structural properties of the two series of chalcogen
analogues of amino acids in peptides and proteins, the methionine and the serine/cysteine …

The main benefit of natural peptides, peptide analogs and newly designed peptides as
therapeutics, lies in their high selectivity and affinity, which are frequently in the nanomolar …