Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …

Epilepsy is common in patients with brain tumours and can substantially affect daily life,
even if the tumour is under control. Several factors affect the mechanism of seizures in brain …

Although no randomized studies have demonstrated a positive impact of therapeutic drug
monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies …

Stroke is the leading cause of seizures and epilepsy in older adults. Patients who have
larger and more severe strokes involving the cortex, are younger, and have acute …

The focus of perioperative pain management should be to attempt to minimise the
nociceptive input and reduce the risk of transition to central sensitisation. Gabapentinoids …

The gabapentinoids are often recommended as first-line treatments for the management of
neuropathic pain. The differing pharmacodynamic and pharmacokinetic profiles can have …

Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by
the known mechanisms of action of the offending agent, do not occur at any dose in most …

Background Management of geriatric patients would be simplified if a universally accepted
definition of frailty for clinical use was defined. Among definitions of frailty, Fried frailty …

Pharmacokinetic and pharmacodynamic changes occur with increasing age. Sex
differences in pharmacokinetics and pharmacodynamics exist and persist at older age. The …

Older adults represent a highly heterogeneous population, with multiple diverse subgroups.
Therefore, an individualized approach to treatment is essential to meet the needs of each …