Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Cells modulate their activities in response to signals from their surrounding environment.
Single cell organisms respond mainly to nutrient cues, many of which are able to cross the …

A cDNA clone encoding a novel, widely expressed protein (called growth factor receptor-
bound protein 2 or GRBP) containing one src homology 2 (SH2) domain and two SH3 …

Phosphoinositide-specific phospholipase C (PLC) subtypes β, γ, and δ comprise a related
group of multidomain phosphodiesterases that cleave the polar head groups from inositol …

Src homology (SH) regions 2 and 3 are noncatalytic domains that are conserved among a
series of cytoplasmic signaling proteins regulated by receptor protein-tyrosine kinases …

Generation, Control, and Processing of Cellular Calcium Signals Page 1 107 1040-9238/01/$.50
© 2001 by CRC Press LLC Critical Reviews in Biochemistry and Molecular Biology, 36(2):107–260 …

Cell-ceil communication is crucial for the develop ment and subsequent survival of
multicellular organisms. A great variety of cellular signals induced by secreted polypeptides …

Oncogenes were first described as retrovirus-encoded genes that produced tumors in birds
and rodents. These genes were then shown to be dominant mutated forms of host genes …

Severe norpA mutations in Drosophila eliminate the photoreceptor potential and render the
fly completely blind. Recent biochemical analyses have shown that norpA mutants lack …

Phospholipase Cγ1 (PLCγ1) and p21ras guanosine triphosphatase (GTPase) activating
protein (GAP) bind to and are phosphorylated by activated growth factor receptors. Both …