Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …

We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Abstract Randomized Controlled Trials (RCTs) are increasingly popular in the social
sciences, not only in medicine. We argue that the lay public, and sometimes researchers, put …

More frequent and intense periods of extreme heat (heatwaves) represent the most direct
challenge to human health posed by climate change. Older adults are particularly …

Internalizing conditions of psychopathology include depressive and anxiety disorders; they
most often onset in adolescence, are relatively common, and contribute to significant …

Background The World Health Organization (WHO) stated in March 2016 that there was
scientific consensus that the mosquito-borne Zika virus was a cause of the neurological …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

Background Quantification of the disease burden caused by different risks informs
prevention by providing an account of health loss different to that provided by a disease-by …

In this tutorial, we provide a broad introduction to the topic of interaction between the effects
of exposures. We discuss interaction on both additive and multiplicative scales using risks …

Authors often do not give sufficient information to draw conclusions about the size and
statistical significance of interaction on the additive and multiplicative scales. To improve …