ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis
ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
A Bolomsky, M Ceribelli, S Scheich, K Rinaldi… - Cancer Cell, 2024 - cell.com
Multiple myeloma (MM) is an incurable plasma cell malignancy that exploits transcriptional
networks driven by IRF4. We employ a multi-omics approach to discover IRF4 …
networks driven by IRF4. We employ a multi-omics approach to discover IRF4 …
Transcription factor dependencies identify BAF-dependent cancers
HM McRae, DC Hargreaves - Cancer Cell, 2024 - Elsevier
In Cancer Cell, Bolomsky et al., Duplaquet et al., and He et al. identify cancers that are
dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple …
dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple …
SWI/SNF regulation of germinal center fate and lymphomagenesis
Q Sievers, O Abdel-Wahab - Cancer Cell, 2024 - Elsevier
The mSWI/SNF subunits ARID1A and SMARCA4 are mutated in B cell lymphomas. Now,
Barisic et al. and Deng et al. find that loss of ARID1A or SMARCA4 contributes to …
Barisic et al. and Deng et al. find that loss of ARID1A or SMARCA4 contributes to …