Antimicrobial peptides are a vital component of the innate immune system of all eukaryotic
organisms and many of these peptides have potent antifungal activity. They have potential …

The incidence of invasive fungal infections is increasing worldwide, resulting in more than
1.6 million deaths every year. Due to growing antifungal drug resistance and the limited …

The underlying mechanisms of Candida and candidiasis and promising new directions in
drug discovery and treatment.• Reviews all aspects of this common fungal pathogen and its …

Histatins are salivary cationic peptides that provide the first line of defense against oral
candidiasis caused by Candida albicans. This minireview presents a critical evaluation of …

ABSTRACT Human β-defensin 2 (hBD-2) and hBD-3 have potent fungicidal activity in the
micromolar range. Although little is known about their mechanism of action against Candida …

ABSTRACT Histatin 5 (Hst 5) is a salivary cationic peptide that has toxicity for Candida
albicans by inducing rapid cellular ion imbalance and cell volume loss. Microarray analyses …

Background Enthusiasm for the use of metal nanoparticles in human and veterinary
medicine is high. Many articles describe the effects of metal nanoparticles on microbes in …

HIV-infected individuals constitute a population highly susceptible to opportunistic infections,
particularly oral candidiasis caused by the most pathogenic human fungal species Candida …

Systemic candidiasis is a growing health care concern that is becoming even more
challenging due to the growing frequency of infections caused by multidrug-resistant (MDR) …

The activity of histatin 5 (Hst 5) against Candida albicans is initiated through cell wall
binding, followed by translocation and intracellular targeting. The C. albicans cell wall …