Fibrinogen and fibrin in hemostasis and thrombosis
S Kattula, JR Byrnes, AS Wolberg - … , thrombosis, and vascular …, 2017 - Am Heart Assoc
Multiple mechanisms mediate thrombin generation and consequently the thrombin
concentration present during fibrin formation. First, the levels of pro-and anticoagulants …
concentration present during fibrin formation. First, the levels of pro-and anticoagulants …
[HTML][HTML] Fibrin (ogen) in human disease: both friend and foe
Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma
at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 …
at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 …
[HTML][HTML] Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
Post-COVID cognitive deficits, including 'brain fog', are clinically complex, with both objective
and subjective components. They are common and debilitating, and can affect the ability to …
and subjective components. They are common and debilitating, and can affect the ability to …
COVID-19 and sepsis are associated with different abnormalities in plasma procoagulant and fibrinolytic activity
EG Bouck, F Denorme, LA Holle… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Coronavirus disease 2019 (COVID-19) is associated with derangement in
biomarkers of coagulation and endothelial function and has been likened to the …
biomarkers of coagulation and endothelial function and has been likened to the …
Venous thrombosis
Venous thromboembolism (VTE) encompasses deep-vein thrombosis (DVT) and pulmonary
embolism. VTE is the leading cause of lost disability-adjusted life years and the third leading …
embolism. VTE is the leading cause of lost disability-adjusted life years and the third leading …
Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited
Virchow's triad is traditionally invoked to explain pathophysiologic mechanisms leading to
thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall …
thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall …
Cytokine storm associated coagulation complications in COVID-19 patients: Pathogenesis and Management
ABSTRACT Introduction SARS-CoV-2, the causative agent of COVID-19, attacks the
immune system causing an exaggerated and uncontrolled release of pro-inflammatory …
immune system causing an exaggerated and uncontrolled release of pro-inflammatory …
Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: Effects on weight loss and safety in adults with overweight or obesity
MH Friedrichsen, L Endahl, FF Kreiner, R Goldwater… - Molecular …, 2023 - Elsevier
Objective Glucagon/glucagon-like peptide-1 (GLP-1) receptor co-agonists may provide
greater weight loss than agonists targeting the GLP-1 receptor alone. We report results from …
greater weight loss than agonists targeting the GLP-1 receptor alone. We report results from …
Fibrinogen and fibrin: synthesis, structure, and function in health and disease
AS Wolberg - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
Fibrinogen is an extraordinary molecule by any estimation. It is large, structurally intricate,
and circulates at high concentrations. Its biological end product, insoluble fibrin (ogen) or …
and circulates at high concentrations. Its biological end product, insoluble fibrin (ogen) or …
Fibrinolysis and inflammation in venous thrombus resolution
S Mukhopadhyay, TA Johnson, N Duru… - Frontiers in …, 2019 - frontiersin.org
Clinical observations and accumulating laboratory evidence support a complex interplay
between coagulation, inflammation, innate immunity and fibrinolysis in venous …
between coagulation, inflammation, innate immunity and fibrinolysis in venous …